Abstract
Muscle-invasive or metastatic bladder cancer (BCa) is a life-threatening disease for patients, and tumor angiogenesis is believed to play a critical role in the progression of BCa. However, its underlying mechanism of tumor angiogenesis is still poorly understood. In this study, we discovered that RASAL2, a RAS GTPase activating protein, could inhibit BCa angiogenesis based on our shRNA/siRNA knockdown or ectopic cDNA expression experiments. Mechanistically, RASAL2 downregulation could enhance the phosphorylation of AKT and then subsequently upregulate the expression of ETS1 and VEGFA. Furthermore, there was a negative correlation between RASAL2 and VEGFA or CD31 expression in subcutaneous xenograft and human BCa specimens. Taken together, we provide a new insight into the molecular mechanism of BCa progression, in which RASAL2 can be a new therapeutic target.
Original language | English (US) |
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Pages (from-to) | 38-44 |
Number of pages | 7 |
Journal | Cellular Signalling |
Volume | 48 |
DOIs | |
State | Published - Aug 2018 |
Keywords
- AKT/ETS1 signaling
- Angiogenesis
- Bladder cancer
- RASAL2
- VEGFA
ASJC Scopus subject areas
- Cell Biology