Ratio between forced expiratory flow between 25% and 75% of vital capacity and FVC is a determinant of airway reactivity and sensitivity to methacholine

Annie Lin Parker, Muhanned Abu-Hijleh, F. Dennis McCool

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Study objective: The ratio between forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) and FVC is thought to reflect dysanapsis between airway size and lung size. A low FEF25-75/FVC ratio is associated with airway responsiveness to methacholine in middle-aged and older men. The current study was designed to assess this relationship in both male and female subjects over a broader range of ages. Study design: Data analysis of consecutive subjects who had a ≥ 20% reduction in FEV1 after ≤ 189 cumulative units of methacholine over a 7-year period. Setting: Pulmonary function laboratory in a university-affiliated hospital. Patients: A total of 764 consecutive subjects aged 4 to 91 years (mean ± SD age, 40.8 ± 19.6 years). There were 223 male (29.3%) and 540 female (70.7%) subjects. Measurements and results: Airway reactivity was assessed as the dose-response slope of the reduction in FEV1 from baseline vs the cumulative dose of inhaled methacholine. The cumulative dose of methacholine causing 20% reduction in FEV1 (PD20) was used as the indicator of airway sensitivity. In a linear regression model that included age, height, and percentage of predicted FEV1, the FEF25-75/FVC ratio accounted for 7.6% of variability in airway reactivity (p < 0.0001, r2 = 0.076). Subjects with higher airway sensitivity, indicated by lower PD20, also had a lower FEF25-75/FVC ratio. Conclusions: A low FEF25-75/FVC ratio, indicating small airway size relative to lung size, is associated with higher airway sensitivity and reactivity to methacholine in susceptible subjects.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalChest
Volume124
Issue number1
DOIs
StatePublished - Jul 1 2003

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Methacholine Chloride
Vital Capacity
Lung
Linear Models

Keywords

  • Airway reactivity
  • Airway sensitivity
  • Dysanapsis
  • Methacholine

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ratio between forced expiratory flow between 25% and 75% of vital capacity and FVC is a determinant of airway reactivity and sensitivity to methacholine. / Parker, Annie Lin; Abu-Hijleh, Muhanned; McCool, F. Dennis.

In: Chest, Vol. 124, No. 1, 01.07.2003, p. 63-69.

Research output: Contribution to journalArticle

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abstract = "Study objective: The ratio between forced expiratory flow between 25{\%} and 75{\%} of vital capacity (FEF25-75) and FVC is thought to reflect dysanapsis between airway size and lung size. A low FEF25-75/FVC ratio is associated with airway responsiveness to methacholine in middle-aged and older men. The current study was designed to assess this relationship in both male and female subjects over a broader range of ages. Study design: Data analysis of consecutive subjects who had a ≥ 20{\%} reduction in FEV1 after ≤ 189 cumulative units of methacholine over a 7-year period. Setting: Pulmonary function laboratory in a university-affiliated hospital. Patients: A total of 764 consecutive subjects aged 4 to 91 years (mean ± SD age, 40.8 ± 19.6 years). There were 223 male (29.3{\%}) and 540 female (70.7{\%}) subjects. Measurements and results: Airway reactivity was assessed as the dose-response slope of the reduction in FEV1 from baseline vs the cumulative dose of inhaled methacholine. The cumulative dose of methacholine causing 20{\%} reduction in FEV1 (PD20) was used as the indicator of airway sensitivity. In a linear regression model that included age, height, and percentage of predicted FEV1, the FEF25-75/FVC ratio accounted for 7.6{\%} of variability in airway reactivity (p < 0.0001, r2 = 0.076). Subjects with higher airway sensitivity, indicated by lower PD20, also had a lower FEF25-75/FVC ratio. Conclusions: A low FEF25-75/FVC ratio, indicating small airway size relative to lung size, is associated with higher airway sensitivity and reactivity to methacholine in susceptible subjects.",
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