Rational design of amyloid binding agents based on the molecular rotor motif

Jeyanthy Sutharsan, Marianna Dakanali, Christina C. Capule, Mark A. Haidekker, Jerry Yang, Emmanuel A. Theodorakis

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalChemMedChem
Volume5
Issue number1
DOIs
StatePublished - Jan 4 2010

Fingerprint

Amyloid
Rotors
Fluorescent Dyes
Alzheimer Disease
Fluorescence
Imaging techniques
Peptides

Keywords

  • Amyloid peptides
  • Fluorescent probes
  • Imaging agents
  • Molecular rotors

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

Sutharsan, J., Dakanali, M., Capule, C. C., Haidekker, M. A., Yang, J., & Theodorakis, E. A. (2010). Rational design of amyloid binding agents based on the molecular rotor motif. ChemMedChem, 5(1), 56-60. https://doi.org/10.1002/cmdc.200900440

Rational design of amyloid binding agents based on the molecular rotor motif. / Sutharsan, Jeyanthy; Dakanali, Marianna; Capule, Christina C.; Haidekker, Mark A.; Yang, Jerry; Theodorakis, Emmanuel A.

In: ChemMedChem, Vol. 5, No. 1, 04.01.2010, p. 56-60.

Research output: Contribution to journalArticle

Sutharsan, J, Dakanali, M, Capule, CC, Haidekker, MA, Yang, J & Theodorakis, EA 2010, 'Rational design of amyloid binding agents based on the molecular rotor motif', ChemMedChem, vol. 5, no. 1, pp. 56-60. https://doi.org/10.1002/cmdc.200900440
Sutharsan, Jeyanthy ; Dakanali, Marianna ; Capule, Christina C. ; Haidekker, Mark A. ; Yang, Jerry ; Theodorakis, Emmanuel A. / Rational design of amyloid binding agents based on the molecular rotor motif. In: ChemMedChem. 2010 ; Vol. 5, No. 1. pp. 56-60.
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