Rationale and design of the Kidney Precision Medicine Project

Kidney Precision Medicine Project

doi:10.1016/j.kint.2020.08.039

Rationale and design of the Kidney Precision Medicine Project

Kidney Precision Medicine Project

Research output: Contribution to journal › Comment/debate › peer-review

80 Scopus citations

Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

Original language	English (US)
Pages (from-to)	498-510
Number of pages	13
Journal	Kidney international
Volume	99
Issue number	3
DOIs	https://doi.org/10.1016/j.kint.2020.08.039
State	Published - Mar 2021

Keywords

acute kidney injury
chronic kidney disease
diabetes
hypertension
precision medicine

ASJC Scopus subject areas

Nephrology

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10.1016/j.kint.2020.08.039

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title = "Rationale and design of the Kidney Precision Medicine Project",

abstract = "Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.",

keywords = "acute kidney injury, chronic kidney disease, diabetes, hypertension, precision medicine",

author = "{Kidney Precision Medicine Project} and {de Boer}, {Ian H.} and Alpers, {Charles E.} and Azeloglu, {Evren U.} and Balis, {Ulysses G.J.} and Barasch, {Jonathan M.} and Laura Barisoni and Blank, {Kristina N.} and Bomback, {Andrew S.} and Keith Brown and Dagher, {Pierre C.} and Dighe, {Ashveena L.} and Eadon, {Michael T.} and El-Achkar, {Tarek M.} and Gaut, {Joseph P.} and Nir Hacohen and Yongqun He and Hodgin, {Jeffrey B.} and Sanjay Jain and Kellum, {John A.} and Krzysztof Kiryluk and Richard Knight and Laszik, {Zoltan G.} and Chrysta Lienczewski and Mariani, {Laura H.} and McClelland, {Robyn L.} and Steven Menez and Moledina, {Dennis G.} and Mooney, {Sean D.} and O'Toole, {John F.} and Palevsky, {Paul M.} and Parikh, {Chirag R.} and Poggio, {Emilio D.} and Rosas, {Sylvia E.} and Rosengart, {Matthew R.} and Sarwal, {Minnie M.} and Schaub, {Jennifer A.} and Sedor, {John R.} and Kumar Sharma and Becky Steck and Toto, {Robert D.} and Troyanskaya, {Olga G.} and Vazquez, {Miguel A.} and Asra Kermani and Simon Lee and Christopher Lu and Tyler Miller and Orson Moe and Harold Park and Kamalanathan Sambandam and Jose Torrealba",

note = "Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",

year = "2021",

month = mar,

doi = "10.1016/j.kint.2020.08.039",

language = "English (US)",

volume = "99",

pages = "498--510",

journal = "Kidney international",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Rationale and design of the Kidney Precision Medicine Project

AU - Kidney Precision Medicine Project

AU - de Boer, Ian H.

AU - Alpers, Charles E.

AU - Azeloglu, Evren U.

AU - Balis, Ulysses G.J.

AU - Barasch, Jonathan M.

AU - Barisoni, Laura

AU - Blank, Kristina N.

AU - Bomback, Andrew S.

AU - Brown, Keith

AU - Dagher, Pierre C.

AU - Dighe, Ashveena L.

AU - Eadon, Michael T.

AU - El-Achkar, Tarek M.

AU - Gaut, Joseph P.

AU - Hacohen, Nir

AU - He, Yongqun

AU - Hodgin, Jeffrey B.

AU - Jain, Sanjay

AU - Kellum, John A.

AU - Kiryluk, Krzysztof

AU - Knight, Richard

AU - Laszik, Zoltan G.

AU - Lienczewski, Chrysta

AU - Mariani, Laura H.

AU - McClelland, Robyn L.

AU - Menez, Steven

AU - Moledina, Dennis G.

AU - Mooney, Sean D.

AU - O'Toole, John F.

AU - Palevsky, Paul M.

AU - Parikh, Chirag R.

AU - Poggio, Emilio D.

AU - Rosas, Sylvia E.

AU - Rosengart, Matthew R.

AU - Sarwal, Minnie M.

AU - Schaub, Jennifer A.

AU - Sedor, John R.

AU - Sharma, Kumar

AU - Steck, Becky

AU - Toto, Robert D.

AU - Troyanskaya, Olga G.

AU - Vazquez, Miguel A.

AU - Kermani, Asra

AU - Lee, Simon

AU - Lu, Christopher

AU - Miller, Tyler

AU - Moe, Orson

AU - Park, Harold

AU - Sambandam, Kamalanathan

AU - Torrealba, Jose

PY - 2021/3

Y1 - 2021/3

N2 - Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

AB - Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

KW - acute kidney injury

KW - chronic kidney disease

KW - diabetes

KW - hypertension

KW - precision medicine

UR - http://www.scopus.com/inward/record.url?scp=85101142744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85101142744&partnerID=8YFLogxK

U2 - 10.1016/j.kint.2020.08.039

DO - 10.1016/j.kint.2020.08.039

M3 - Comment/debate

C2 - 33637194

AN - SCOPUS:85101142744

SN - 0085-2538

VL - 99

SP - 498

EP - 510

JO - Kidney international

JF - Kidney international

IS - 3

ER -

Rationale and design of the Kidney Precision Medicine Project

Abstract

Keywords

ASJC Scopus subject areas

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