Reaction mechanism of fructose-2,6-bisphosphatase: A mutation of nucleophilic catalyst, histidine 256, induces an alteration in the reaction pathway

Medicine & Life Sciences

• Phosphofructokinase-2 100%
• Histidine 69%
• Mutation 35%
• Enzymes 34%
• phosphohistidine 16%
• Phosphates 15%
• fructose 2,6-diphosphate 14%
• Water 11%
• Hydroxyl Radical 9%
• Alanine 9%
• Phosphoric Monoester Hydrolases 9%
• Hydrolysis 8%
• Arginine 8%
• Testis 7%
• Phosphotransferases 6%
• Acids 6%
• Liver 4%

Chemical Compounds

• Histidine 59%
• Mutation 53%
• Fructose 26%
• Catalyst 26%
• Fructose 6-Phosphate 17%
• Phosphoryl 14%
• Arginine 12%
• Alanine 12%
• Hydrolysis 7%
• Acid 4%