Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

Carl Nathan, Michael U. Shiloh

Research output: Contribution to journalArticle

991 Citations (Scopus)

Abstract

This review summarizes recent evidence from knock-out mice on the role of reactive oxygen intermediates and reactive nitrogen intermediates (RNI) in mammalian immunity. Reflections on redundancy in immunity help explain an apparent paradox: the phagocyte oxidase and inducible nitric oxide synthase are each nonredundant, and yet also mutually redundant, in host defense. In combination, the contribution of these two enzymes appears to be greater than previously appreciated. The remainder of this review focuses on a relatively new field, the basis of microbial resistance to RNI. Experimental tuberculosis provides an important example of an extended, dynamic balance between host and pathogen in which RNI play a major role. In diseases such as tuberculosis, a molecular understanding of host-pathogen interactions requires characterization of the defenses used by microbes against RNI, analogous to our understanding of defenses against reactive oxygen intermediates. Genetic and biochemical approaches have identified candidates for RNI-resistance genes in Mycobacterium tuberculosis and other pathogens.

Original languageEnglish (US)
Pages (from-to)8841-8848
Number of pages8
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number16
DOIs
StatePublished - Aug 1 2000

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Nitrogen
Oxygen
Immunity
Tuberculosis
Host-Pathogen Interactions
Nitric Oxide Synthase Type II
Phagocytes
Mycobacterium tuberculosis
Knockout Mice
Molecular Biology
Oxidoreductases
Enzymes
Genes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

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