Readers, writers, and erasers: Chromatin as the whiteboard of heart disease

Thomas G. Gillette, Joseph A Hill

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification - driven by the actions of modifiers and recruitment of downstream effectors - is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.

Original languageEnglish (US)
Pages (from-to)1245-1253
Number of pages9
JournalCirculation Research
Volume116
Issue number7
DOIs
StatePublished - Mar 27 2015

Keywords

  • Chromatin
  • Chromatin assembly and disassembly
  • Epigenomics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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