Readers, writers, and erasers

Chromatin as the whiteboard of heart disease

Thomas G. Gillette, Joseph A Hill

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification - driven by the actions of modifiers and recruitment of downstream effectors - is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.

Original languageEnglish (US)
Pages (from-to)1245-1253
Number of pages9
JournalCirculation Research
Volume116
Issue number7
DOIs
StatePublished - Mar 27 2015

Fingerprint

Histone Code
Chromatin
Heart Diseases
DNA Packaging
Nucleosomes
RNA Polymerase II
Eukaryotic Cells
Post Translational Protein Processing
Histones
Transcriptional Activation
Myocardium
Homeostasis
RNA
Gene Expression
DNA
Growth

Keywords

  • Chromatin
  • Chromatin assembly and disassembly
  • Epigenomics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Readers, writers, and erasers : Chromatin as the whiteboard of heart disease. / Gillette, Thomas G.; Hill, Joseph A.

In: Circulation Research, Vol. 116, No. 7, 27.03.2015, p. 1245-1253.

Research output: Contribution to journalArticle

@article{a9958a8bd2c34ab8ab7cdf1dd65fd056,
title = "Readers, writers, and erasers: Chromatin as the whiteboard of heart disease",
abstract = "Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification - driven by the actions of modifiers and recruitment of downstream effectors - is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.",
keywords = "Chromatin, Chromatin assembly and disassembly, Epigenomics",
author = "Gillette, {Thomas G.} and Hill, {Joseph A}",
year = "2015",
month = "3",
day = "27",
doi = "10.1161/CIRCRESAHA.116.303630",
language = "English (US)",
volume = "116",
pages = "1245--1253",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Readers, writers, and erasers

T2 - Chromatin as the whiteboard of heart disease

AU - Gillette, Thomas G.

AU - Hill, Joseph A

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification - driven by the actions of modifiers and recruitment of downstream effectors - is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.

AB - Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification - driven by the actions of modifiers and recruitment of downstream effectors - is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.

KW - Chromatin

KW - Chromatin assembly and disassembly

KW - Epigenomics

UR - http://www.scopus.com/inward/record.url?scp=84940079857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940079857&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.116.303630

DO - 10.1161/CIRCRESAHA.116.303630

M3 - Article

VL - 116

SP - 1245

EP - 1253

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 7

ER -