Ready, pause, go: Regulation of RNA polymerase II pausing and release by cellular signaling pathways

Xiuli Liu, W. Lee Kraus, Xiaoying Bai

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to control the timing, rate, and possibly the magnitude of transcriptional responses. Recent studies have shown that cellular signaling pathways can regulate gene transcription and signaling outcomes by controlling Pol II pausing in a wide array of biological systems. Identification of the proteins and small molecules that affect the establishment and release of paused Pol II is shedding new light on the mechanisms and biology of Pol II pausing. This review focuses on the interplay between cellular signaling pathways and Pol II pausing during normal development and under disease conditions.

Original languageEnglish (US)
Pages (from-to)516-525
Number of pages10
JournalTrends in Biochemical Sciences
Volume40
Issue number9
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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