Real-time cerebral angiography

Sensitivity of a new contrast-specific ultrasound technique

Thilo Hölscher, J. A. Sattin, R. Raman, W. Wilkening, C. V. Fanale, S. E. Olson, R. F. Mattrey, P. D. Lyden

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: To test a new contrast-specific sonography imaging method that offers visualization of the intracranial vasculature in a manner similar to that seen on angiography. MATERIALS AND METHODS: Thirty patients (35 sonography studies total) were included in the study after they provided written informed consent. The patients were scanned through the temporal bone window from both sides after intravenous injection of an ultrasound contrast agent (UCA; perflexane lipid microspheres [Imagent]). The goal was to visualize the intracranial arteries, including the middle (M1-M3), anterior (A1 and A2), and posterior (P1-P3) cerebral arteries, using an axial scanning plane. The studies were performed using a contrast-specific imaging mode, based on a phase inversion technique (transcranial ultrasound angiography [tUSA]). For sensitivity, the results were compared with x-ray angiography as the "gold standard." For interobserver reliability, 24 of 35 sonography studies were evaluated by 2 physicians with little training in transcranial sonography and by a seasoned sonographer. RESULTS: The sensitivity of tUSA ranged between 0.778 (95% confidence interval [CI] of 0.577-0.914) and 0.963 (95% CI of 0.810-0.999). The sensitivities were similar among physicians with little training in transcranial sonography and the seasoned sonographer, indicating high inter-rater reliability. Overall, tUSA provided high anatomic resolution and vascular delineation even of small vessels in the millimeter range. At peak intensity, no UCA-related artifacts were observed. CONCLUSION: tUSA provides images of the intracranial arteries similar to those obtained at angiography with high anatomic resolution, reasonable sensitivity, and interobserver reliability.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume28
Issue number4
StatePublished - Apr 1 2007

Fingerprint

Cerebral Angiography
Angiography
Ultrasonography
Arteries
Confidence Intervals
Physicians
Cerebral Arteries
Temporal Bone
Informed Consent
Microspheres
varespladib methyl
Intravenous Injections
Artifacts
Contrast Media
Blood Vessels
X-Rays
Lipids

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hölscher, T., Sattin, J. A., Raman, R., Wilkening, W., Fanale, C. V., Olson, S. E., ... Lyden, P. D. (2007). Real-time cerebral angiography: Sensitivity of a new contrast-specific ultrasound technique. American Journal of Neuroradiology, 28(4), 635-639.

Real-time cerebral angiography : Sensitivity of a new contrast-specific ultrasound technique. / Hölscher, Thilo; Sattin, J. A.; Raman, R.; Wilkening, W.; Fanale, C. V.; Olson, S. E.; Mattrey, R. F.; Lyden, P. D.

In: American Journal of Neuroradiology, Vol. 28, No. 4, 01.04.2007, p. 635-639.

Research output: Contribution to journalArticle

Hölscher, T, Sattin, JA, Raman, R, Wilkening, W, Fanale, CV, Olson, SE, Mattrey, RF & Lyden, PD 2007, 'Real-time cerebral angiography: Sensitivity of a new contrast-specific ultrasound technique', American Journal of Neuroradiology, vol. 28, no. 4, pp. 635-639.
Hölscher T, Sattin JA, Raman R, Wilkening W, Fanale CV, Olson SE et al. Real-time cerebral angiography: Sensitivity of a new contrast-specific ultrasound technique. American Journal of Neuroradiology. 2007 Apr 1;28(4):635-639.
Hölscher, Thilo ; Sattin, J. A. ; Raman, R. ; Wilkening, W. ; Fanale, C. V. ; Olson, S. E. ; Mattrey, R. F. ; Lyden, P. D. / Real-time cerebral angiography : Sensitivity of a new contrast-specific ultrasound technique. In: American Journal of Neuroradiology. 2007 ; Vol. 28, No. 4. pp. 635-639.
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