TY - GEN
T1 - Real-time high spatial resolution, in vivo corneal imaging
T2 - Ophthalmic Technologies XVI
AU - Cavanagh, H. Dwight
AU - Petroll, W. M.
PY - 2006
Y1 - 2006
N2 - Purpose: To identify, characterize, and discuss the current technological status of in vivo comeal diagnostic imaging and target high-priority future development needs. Methods: In vivo tandem scanning microscopy (non-coherent), scanning slit confocal microscopy (non-coherent), and laser scanning confocal microscopy (coherent) are examined. The current and future roles of multi-photon and higher order harmonic imaging are also discussed. Results and Conclusions: This keynote review demonstrates the current abilities and limitations of three currently used clinical imaging modalities to resolve the cellular and structural layers of the cornea temporally and spatially in three or four dimensions (x, y, z, t), with applications to the study of clinical-pathological processes such as inflammation; infection, wound healing, drug toxicity, organ development, differentiation and effects of genetic diseases. Each of these approaches has strengths and weaknesses. Thus, future technological development is essential to provide exciting new insights into understanding the structure and function of not only the cornea and the other ocular structures, but also other multicellular organs in health and disease. These imaging paradigms are among the most important advances in medical science in the past three decades.
AB - Purpose: To identify, characterize, and discuss the current technological status of in vivo comeal diagnostic imaging and target high-priority future development needs. Methods: In vivo tandem scanning microscopy (non-coherent), scanning slit confocal microscopy (non-coherent), and laser scanning confocal microscopy (coherent) are examined. The current and future roles of multi-photon and higher order harmonic imaging are also discussed. Results and Conclusions: This keynote review demonstrates the current abilities and limitations of three currently used clinical imaging modalities to resolve the cellular and structural layers of the cornea temporally and spatially in three or four dimensions (x, y, z, t), with applications to the study of clinical-pathological processes such as inflammation; infection, wound healing, drug toxicity, organ development, differentiation and effects of genetic diseases. Each of these approaches has strengths and weaknesses. Thus, future technological development is essential to provide exciting new insights into understanding the structure and function of not only the cornea and the other ocular structures, but also other multicellular organs in health and disease. These imaging paradigms are among the most important advances in medical science in the past three decades.
KW - Confocal microscopy
KW - Corneal imaging
KW - In vivo microscopy
KW - Non-invasive imaging
UR - http://www.scopus.com/inward/record.url?scp=33745368702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745368702&partnerID=8YFLogxK
U2 - 10.1117/12.663481
DO - 10.1117/12.663481
M3 - Conference contribution
AN - SCOPUS:33745368702
SN - 0819461814
SN - 9780819461810
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Ophthalmic Technologies XVI
Y2 - 21 January 2006 through 24 January 2006
ER -