Real-time sonoelastography of hepatic thermal lesions in a swine model

Man Zhang, Benjamin Castaneda, Jared Christensen, Wael Saad, Kevin Bylund, Kenneth Hoyt, John G. Strang, Deborah J. Rubens, Kevin J. Parker

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Sonoelastography has been developed as an ultrasound-based elasticity imaging technique. In this technique, external vibration is induced into the target tissue. In general, tissue stiffness is inversely proportional to the amplitude of tissue vibration. Imaging tissue vibration will provide the elasticity distribution in the target region. This study investigated the feasibility of using real-time sonoelastography to detect and estimate the volume of thermal lesions in porcine livers in vivo. A total of 32 thermal lesions with volumes ranging from 0.2 to 5.3 cm3 were created using radiofrequency ablation (RFA) or high-intensity focused ultrasound (HIFU) technique. Lesions were imaged using sonoelastography and coregistered B-mode ultrasound. Volumes were reconstructed from a sequence of two-dimensional scans. The comparison of sonoelastographic measurements and pathology findings showed good correlation with respect to the area of the lesions (r2 =0.8823 for RFA lesions, r2 =0.9543 for HIFU lesions). In addition, good correspondence was found between three-dimensional sonoelastography and gross pathology (3.6% underestimate), demonstrating the feasibility of sonoelastography for volume estimation of thermal lesions. These results support that sonoelastography outperforms conventional B-mode ultrasound and could potentially be used for assessment of thermal therapies.

Original languageEnglish (US)
Pages (from-to)4132-4141
Number of pages10
JournalMedical Physics
Volume35
Issue number9
DOIs
StatePublished - Jan 1 2008

Fingerprint

Elasticity Imaging Techniques
Swine
Hot Temperature
Liver
Vibration
High-Intensity Focused Ultrasound Ablation
Pathology
Elasticity
Feasibility Studies

Keywords

  • Coagulation necrosis
  • High-intensity focused ultrasound
  • Liver
  • Radiofrequency ablation
  • Sonoelastography
  • Swine model
  • Thermal lesion

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Zhang, M., Castaneda, B., Christensen, J., Saad, W., Bylund, K., Hoyt, K., ... Parker, K. J. (2008). Real-time sonoelastography of hepatic thermal lesions in a swine model. Medical Physics, 35(9), 4132-4141. https://doi.org/10.1118/1.2968939

Real-time sonoelastography of hepatic thermal lesions in a swine model. / Zhang, Man; Castaneda, Benjamin; Christensen, Jared; Saad, Wael; Bylund, Kevin; Hoyt, Kenneth; Strang, John G.; Rubens, Deborah J.; Parker, Kevin J.

In: Medical Physics, Vol. 35, No. 9, 01.01.2008, p. 4132-4141.

Research output: Contribution to journalArticle

Zhang, M, Castaneda, B, Christensen, J, Saad, W, Bylund, K, Hoyt, K, Strang, JG, Rubens, DJ & Parker, KJ 2008, 'Real-time sonoelastography of hepatic thermal lesions in a swine model', Medical Physics, vol. 35, no. 9, pp. 4132-4141. https://doi.org/10.1118/1.2968939
Zhang M, Castaneda B, Christensen J, Saad W, Bylund K, Hoyt K et al. Real-time sonoelastography of hepatic thermal lesions in a swine model. Medical Physics. 2008 Jan 1;35(9):4132-4141. https://doi.org/10.1118/1.2968939
Zhang, Man ; Castaneda, Benjamin ; Christensen, Jared ; Saad, Wael ; Bylund, Kevin ; Hoyt, Kenneth ; Strang, John G. ; Rubens, Deborah J. ; Parker, Kevin J. / Real-time sonoelastography of hepatic thermal lesions in a swine model. In: Medical Physics. 2008 ; Vol. 35, No. 9. pp. 4132-4141.
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