TY - JOUR
T1 - Real-world outcomes among US Merkel cell carcinoma patients initiating immune checkpoint inhibitors or chemotherapy
AU - Chandra, Sunandana
AU - Zheng, Ying
AU - Pandya, Shivani
AU - Yu, Ting
AU - Kearney, Mairead
AU - Wang, Li
AU - Kim, Ruth
AU - Phatak, Hemant
N1 - Funding Information:
Statistical programming and medical writing assistance were provided by Y Cao and C Dieyi of STATinMED Research, respectively. Editorial support was provided by M Moriarty, also of STATinMED Research.
PY - 2020/11
Y1 - 2020/11
N2 - Aim: Retrospectively assessed treatment patterns and clinical and economic outcomes in Merkel cell carcinoma (MCC) patients receiving recommended first-line regimens. Materials & methods: MCC patients newly treated with either immune checkpoint inhibitors (ICIs) or chemotherapies (CTs) were selected from the Veterans Health Administration database (2013-2018); 74 patients (ICIs: 20 and CTs: 54) were selected. Results: Median duration of therapy was 300 days for ICIs and 91 days for CTs. Time to next treatment was 245 and 184 days, respectively. Mean total (per patient per month) costs were $15,306 (ICIs) and $10,957 (CTs), of which 51% and 86%, respectively, were non-MCC therapy-related costs. Conclusion: Despite higher costs, utilization of ICIs in first-line MCC shows clinical advantages over CTs in the real world.
AB - Aim: Retrospectively assessed treatment patterns and clinical and economic outcomes in Merkel cell carcinoma (MCC) patients receiving recommended first-line regimens. Materials & methods: MCC patients newly treated with either immune checkpoint inhibitors (ICIs) or chemotherapies (CTs) were selected from the Veterans Health Administration database (2013-2018); 74 patients (ICIs: 20 and CTs: 54) were selected. Results: Median duration of therapy was 300 days for ICIs and 91 days for CTs. Time to next treatment was 245 and 184 days, respectively. Mean total (per patient per month) costs were $15,306 (ICIs) and $10,957 (CTs), of which 51% and 86%, respectively, were non-MCC therapy-related costs. Conclusion: Despite higher costs, utilization of ICIs in first-line MCC shows clinical advantages over CTs in the real world.
KW - Duration of treatment
KW - Health care resource utilization
KW - Immune checkpoint inhibitors
KW - Merkel cell carcinoma
KW - Recommended chemotherapy
KW - Survival
KW - Time to next treatment
KW - Veterans Health Administration
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U2 - 10.2217/fon-2020-0453
DO - 10.2217/fon-2020-0453
M3 - Article
C2 - 32883109
AN - SCOPUS:85097004561
VL - 16
SP - 2521
EP - 2536
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 31
ER -