TY - JOUR
T1 - Rebound after Withdrawal of Nitroprusside
AU - Khambatta, Hoshang J.
AU - Stone, J. Gilbert
AU - Paulshock, Bernadine Z.
AU - Packer, Milton
AU - Meller, Jose
PY - 1980/5/1
Y1 - 1980/5/1
N2 - To the Editor: Vasodilators must alter homeostatic control mechanisms, but biochemical data are just beginning to appear. Gerber and Nies1 commented in their editorial that Packer et al.2 did not measure plasma renin activity or catecholamines before, during, and after administration of nitroprusside to patients with severe chronic heart failure, and that these measurements might have explained the overshoot in arterial pressure seen on abrupt withdrawal of nitroprusside. We have recently reported that abrupt discontinuation of nitroprusside, which was administered to induce hypotension during anesthesia in otherwise healthy patients, resulted in an overshoot in arterial pressure within 30 minutes.3 There.
AB - To the Editor: Vasodilators must alter homeostatic control mechanisms, but biochemical data are just beginning to appear. Gerber and Nies1 commented in their editorial that Packer et al.2 did not measure plasma renin activity or catecholamines before, during, and after administration of nitroprusside to patients with severe chronic heart failure, and that these measurements might have explained the overshoot in arterial pressure seen on abrupt withdrawal of nitroprusside. We have recently reported that abrupt discontinuation of nitroprusside, which was administered to induce hypotension during anesthesia in otherwise healthy patients, resulted in an overshoot in arterial pressure within 30 minutes.3 There.
UR - http://www.scopus.com/inward/record.url?scp=0018850880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018850880&partnerID=8YFLogxK
U2 - 10.1056/NEJM198005013021812
DO - 10.1056/NEJM198005013021812
M3 - Letter
C2 - 6988710
AN - SCOPUS:0018850880
SN - 0028-4793
VL - 302
SP - 1029
EP - 1030
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -