(Re)Building a Kidney

Leif Oxburgh, Thomas J. Carroll, Ondine Cleaver, Daniel R. Gossett, Deborah K. Hoshizaki, Jeffrey A. Hubbell, Benjamin D. Humphreys, Sanjay Jain, Jan Jensen, David L. Kaplan, Carl Kesselman, Christian J. Ketchum, Melissa H. Little, Andrew P. McMahon, Stuart J. Shankland, Jason R. Spence, M. Todd Valerius, Jason A. Wertheim, Oliver Wessely, Ying ZhengIain A. Drummond

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.

Original languageEnglish (US)
Pages (from-to)1370-1378
Number of pages9
JournalJournal of the American Society of Nephrology : JASN
Volume28
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • Directed differentiation
  • Organogenesis
  • Organoid
  • Regeneration

ASJC Scopus subject areas

  • Nephrology

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    Oxburgh, L., Carroll, T. J., Cleaver, O., Gossett, D. R., Hoshizaki, D. K., Hubbell, J. A., Humphreys, B. D., Jain, S., Jensen, J., Kaplan, D. L., Kesselman, C., Ketchum, C. J., Little, M. H., McMahon, A. P., Shankland, S. J., Spence, J. R., Valerius, M. T., Wertheim, J. A., Wessely, O., ... Drummond, I. A. (2017). (Re)Building a Kidney. Journal of the American Society of Nephrology : JASN, 28(5), 1370-1378. https://doi.org/10.1681/ASN.2016101077