Recent advances in antiviral interferon-stimulated gene biology

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.

Original languageEnglish (US)
Article number309
JournalF1000Research
Volume7
DOIs
StatePublished - Jan 1 2018

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Interferons
Antiviral Agents
Genes
Pathogens
Screening
Technology

Keywords

  • Antiviral interferon-stimulated genes
  • Interferon response
  • Viral pathogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Recent advances in antiviral interferon-stimulated gene biology. / Schoggins, John W.

In: F1000Research, Vol. 7, 309, 01.01.2018.

Research output: Contribution to journalReview article

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