Recent advances in Barrett's esophagus

John Inadomi, Hani Alastal, Luigi Bonavina, Seth Gross, Richard H. Hunt, Hiroshi Mashimo, Massimiliano di Pietro, Horace Rhee, Marmy Shah, Salvatore Tolone, David H. Wang, Shao Hua Xie

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma, one of the few cancers with increasing incidence in developed countries. The pathogenesis of BE is unclear with regard to either the cellular origin of this metaplastic epithelium or the manner in which malignant transformation occurs, although recent data indicate a possible junctional origin of stem cells for BE. Treatment of BE may be achieved using endoscopic eradication therapy; however, there is a lack of discriminatory tools to identify individuals at sufficient risk for cancer development in whom intervention is warranted. Reduction in gastroesophageal reflux of gastric contents including acid is mandatory to achieve remission from BE after endoscopic ablation, and can be achieved using medical or nonmedical interventions. Research topics of greatest interest include the mechanism of BE development and transformation to cancer, risk stratification methods to identify individuals who may benefit from ablation of BE, optimization of eradication therapy, and surveillance methods to ensure that remission is maintained after eradication is achieved.

Original languageEnglish (US)
JournalAnnals of the New York Academy of Sciences
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Barrett's esophagus
  • Endoscopy
  • Esophageal adenocarcinoma
  • Imaging
  • Screening
  • Surveillance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Inadomi, J., Alastal, H., Bonavina, L., Gross, S., Hunt, R. H., Mashimo, H., di Pietro, M., Rhee, H., Shah, M., Tolone, S., Wang, D. H., & Xie, S. H. (Accepted/In press). Recent advances in Barrett's esophagus. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.13909