Recent advances in copper radiopharmaceuticals

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Copper has five radioisotopes (60Cu, 61Cu, 62Cu, 64Cu, and 67Cu) that can be used in copper radiopharmaceuticals. These radioisotopes decay by mixed emissions of β+, β-, and γ with a wide range of half-lives from 9.74 min (62Cu) to 2.58 d (67Cu), which enable the design and synthesis of a variety of radiopharmaceuticals for different biomedical applications in diagnostic and therapeutic nuclear medicine. However, due to the availability and production cost, the research efforts in copper radiopharmaceuticals are mainly focused on the use of 64Cu (t1/2 = 12.7 h; 17.4% β+, 43% EC, 39% β-), a radioisotope with low positron energy (Eβ+max = 0.656 MeV) that is ideal for positron emission tomography (PET) imaging quantification and β- emissions along with Auger electron for radiotherapy. Driven by the ever-increasing availability of preclinical and clinical PET scanners, a considerable interest has been seen in the development of novel copper radiopharmaceuticals in the past decade for a variety of diseases as represented by PET imaging of cancer. To avoid unnecessary literature redundancy, this review focuses on the unrepresented research aspects of copper chemistry (e.g. electrochemistry) and their uses in the evaluation of novel nuclear imaging probe design and recent advances in the field towards the practical use of copper radiopharmaceuticals.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalCurrent Radiopharmaceuticals
Volume4
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • And molecular imaging
  • Bifunctional chelator
  • Copper radioisotope
  • Imaging probe
  • Immuno-PET
  • Multivalent effect
  • Non-standard PET nuclide
  • PET
  • Radioimmunoconjugate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pharmacology

Fingerprint Dive into the research topics of 'Recent advances in copper radiopharmaceuticals'. Together they form a unique fingerprint.

  • Cite this