Recent advances in understanding and management of acquired thrombocytopenia

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

There are numerous congenital and acquired causes of thrombocytopenia. Thrombocytopenia could be a result of decreased bone marrow production, increased consumption, increased destruction, splenic sequestration or a combination of these causes. In this review, we have focused on some of the serious acquired causes of thrombocytopenia. There have been some significant advances in our understanding of the pathophysiology, diagnostic testing, and treatment of immune thrombocytopenia, heparin-induced thrombocytopenia, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome over the past five years. These advances have resulted in a significant decrease in mortality and morbidity of patients with these disorders. Despite these advances, we are still faced with numerous unanswered questions in the pathophysiology and management of these complex thrombocytopenic disorders.

Original languageEnglish (US)
Article number68
JournalF1000Research
Volume7
DOIs
StatePublished - Jan 1 2018

Fingerprint

Thrombocytopenia
Heparin
Bone
Testing
Thrombotic Thrombocytopenic Purpura
Idiopathic Thrombocytopenic Purpura
Bone Marrow
Morbidity
Mortality
Therapeutics

Keywords

  • Atypical hemolytic uremic
  • Heparin
  • Immune
  • Thrombocytopenia
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Recent advances in understanding and management of acquired thrombocytopenia. / Sarode, Ravindra; Nagalla, Srikanth.

In: F1000Research, Vol. 7, 68, 01.01.2018.

Research output: Contribution to journalReview article

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