TY - JOUR
T1 - Recent advances in visible light-induced C(sp 3)–N bond formation
AU - Rivas, Mónica
AU - Palchykov, Vitalii
AU - Jia, Xiangqing
AU - Gevorgyan, Vladimir
N1 - Funding Information:
The authors thank the National Institutes of Health (NIH) (GM120281; F31GM139395), National Science Foundation (CHE-1955663), Welch Foundation (Chair, AT-0041) and Eugene McDermott Graduate Fellowship (202007) for financial support.
Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2022/8
Y1 - 2022/8
N2 - Synthetic chemists have long focused on selective C(sp3)–N bond-forming approaches in response to the high value of this motif in natural products, pharmaceutical agents and functional materials. In recent years, visible light-induced protocols have become an important synthetic platform to promote this transformation under mild reaction conditions. These photo-driven methods rely on converting visible light into chemical energy to generate reactive but controllable radical species. This Review highlights recent advances in this area, mostly after 2014, with an emphasis placed on C(sp3)–H bond activations, including amination of olefins and carbonyl compounds, and cross-coupling reactions. [Figure not available: see fulltext.].
AB - Synthetic chemists have long focused on selective C(sp3)–N bond-forming approaches in response to the high value of this motif in natural products, pharmaceutical agents and functional materials. In recent years, visible light-induced protocols have become an important synthetic platform to promote this transformation under mild reaction conditions. These photo-driven methods rely on converting visible light into chemical energy to generate reactive but controllable radical species. This Review highlights recent advances in this area, mostly after 2014, with an emphasis placed on C(sp3)–H bond activations, including amination of olefins and carbonyl compounds, and cross-coupling reactions. [Figure not available: see fulltext.].
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U2 - 10.1038/s41570-022-00403-8
DO - 10.1038/s41570-022-00403-8
M3 - Review article
C2 - 37034136
AN - SCOPUS:85134065059
SN - 2397-3358
VL - 6
SP - 544
EP - 561
JO - Nature Reviews Chemistry
JF - Nature Reviews Chemistry
IS - 8
ER -