Recent cocaine use and the incidence of hemodynamic events during general anesthesia: A retrospective cohort study

Tiffany S Moon, Michael X. Gonzales, Joshua J. Sun, Agnes Kim, Pamela E Fox, Abu Taher M Minhajuddin, Taylor J. Pak, Babatunde O Ogunnaike

Research output: Contribution to journalArticle


Study objective: To evaluate the intraoperative hemodynamics and medication requirements of cocaine-positive patients compared to matched cocaine-negative controls. Design: Retrospective cohort study. Setting: Public county hospital. Patients: 821 patients undergoing general anesthesia. Measurements: Incidence of hemodynamic events, defined by a mean arterial pressure of <65 mmHg or >105 mmHg or a heart rate of <50 beats per minute or >100 beats per minute. Main results: Cocaine-positive patients did not experience a higher incidence of hemodynamic events when compared with matched cocaine-negative patients. Cocaine-positive patients were not more likely to be administered vasopressors intraoperatively but did receive more anti-hypertensive agents. The minimum alveolar concentration of anesthetics used was similar between the two groups. Anesthesia duration, length of stay, and in-hospital mortality did not significantly differ between the two cohorts. Conclusions: Cocaine-positive patients did not demonstrate more intraoperative hemodynamic events or adverse short-term outcomes as compared to matched cocaine-negative controls.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalJournal of Clinical Anesthesia
Publication statusPublished - Aug 1 2019



  • Anesthesia
  • Cocaine-related disorders
  • Hemodynamics
  • Intraoperative care
  • Vasopressors

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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