Recent developments for the efficient crystallographic refinement of macromolecular structures

Axel T. Brünger, Paul D. Adams, Luke M. Rice

Research output: Contribution to journalArticle

81 Scopus citations


Macromolecular crystallographic refinement has recently been made more efficient by the use of cross-validated maximum likelihood targets and torsion-angle molecular dynamics simulated annealing. In combination with automated model building methods, the amount of manual intervention required to complete and refine a structure is greatly reduced.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number5
StatePublished - Oct 1998


ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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