Recent insights into non-nuclear actions of estrogen receptor alpha

Subhashis Banerjee, Ken L. Chambliss, Chieko Mineo, Philip W. Shaul

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Estrogen receptors (ER) classically function as transcription factors regulating gene expression. More recently, evidence has continued to accumulate that ER additionally serve numerous important functions remote from the nucleus in a variety of cell types, particularly in non-reproductive tissues. The identification of post-translational modifications of ERα and protein-protein interactions with the receptor that are critical to its non-nuclear functions has afforded opportunities to gain greater insights into these novel non-genomic roles of the receptor. The development of a stable ligand that selectively activates non-nuclear ER has also been invaluable. In this review focused on ERα, recent new understanding of the processes underlying non-nuclear ER action and their in vivo consequences will be discussed. Further research into the non-nuclear capacities by which ER modulate cellular behavior is essential to ultimately harnessing these processes for therapeutic gain in numerous disease contexts.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalSteroids
Volume81
DOIs
StatePublished - 2014

Fingerprint

Estrogen Receptor alpha
Estrogen Receptors
Post Translational Protein Processing
Gene expression
Transcription Factors
Tissue
Ligands
Gene Expression
Research
Proteins

Keywords

  • Bone mineralization
  • Caveolae
  • Endothelium
  • Estrogen receptor
  • Nitric oxide synthase
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

Cite this

Recent insights into non-nuclear actions of estrogen receptor alpha. / Banerjee, Subhashis; Chambliss, Ken L.; Mineo, Chieko; Shaul, Philip W.

In: Steroids, Vol. 81, 2014, p. 64-69.

Research output: Contribution to journalArticle

Banerjee, Subhashis ; Chambliss, Ken L. ; Mineo, Chieko ; Shaul, Philip W. / Recent insights into non-nuclear actions of estrogen receptor alpha. In: Steroids. 2014 ; Vol. 81. pp. 64-69.
@article{85530405b97545f9a3a2f06e845e4d0d,
title = "Recent insights into non-nuclear actions of estrogen receptor alpha",
abstract = "Estrogen receptors (ER) classically function as transcription factors regulating gene expression. More recently, evidence has continued to accumulate that ER additionally serve numerous important functions remote from the nucleus in a variety of cell types, particularly in non-reproductive tissues. The identification of post-translational modifications of ERα and protein-protein interactions with the receptor that are critical to its non-nuclear functions has afforded opportunities to gain greater insights into these novel non-genomic roles of the receptor. The development of a stable ligand that selectively activates non-nuclear ER has also been invaluable. In this review focused on ERα, recent new understanding of the processes underlying non-nuclear ER action and their in vivo consequences will be discussed. Further research into the non-nuclear capacities by which ER modulate cellular behavior is essential to ultimately harnessing these processes for therapeutic gain in numerous disease contexts.",
keywords = "Bone mineralization, Caveolae, Endothelium, Estrogen receptor, Nitric oxide synthase, Vascular smooth muscle",
author = "Subhashis Banerjee and Chambliss, {Ken L.} and Chieko Mineo and Shaul, {Philip W.}",
year = "2014",
doi = "10.1016/j.steroids.2013.11.002",
language = "English (US)",
volume = "81",
pages = "64--69",
journal = "Steroids",
issn = "0039-128X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Recent insights into non-nuclear actions of estrogen receptor alpha

AU - Banerjee, Subhashis

AU - Chambliss, Ken L.

AU - Mineo, Chieko

AU - Shaul, Philip W.

PY - 2014

Y1 - 2014

N2 - Estrogen receptors (ER) classically function as transcription factors regulating gene expression. More recently, evidence has continued to accumulate that ER additionally serve numerous important functions remote from the nucleus in a variety of cell types, particularly in non-reproductive tissues. The identification of post-translational modifications of ERα and protein-protein interactions with the receptor that are critical to its non-nuclear functions has afforded opportunities to gain greater insights into these novel non-genomic roles of the receptor. The development of a stable ligand that selectively activates non-nuclear ER has also been invaluable. In this review focused on ERα, recent new understanding of the processes underlying non-nuclear ER action and their in vivo consequences will be discussed. Further research into the non-nuclear capacities by which ER modulate cellular behavior is essential to ultimately harnessing these processes for therapeutic gain in numerous disease contexts.

AB - Estrogen receptors (ER) classically function as transcription factors regulating gene expression. More recently, evidence has continued to accumulate that ER additionally serve numerous important functions remote from the nucleus in a variety of cell types, particularly in non-reproductive tissues. The identification of post-translational modifications of ERα and protein-protein interactions with the receptor that are critical to its non-nuclear functions has afforded opportunities to gain greater insights into these novel non-genomic roles of the receptor. The development of a stable ligand that selectively activates non-nuclear ER has also been invaluable. In this review focused on ERα, recent new understanding of the processes underlying non-nuclear ER action and their in vivo consequences will be discussed. Further research into the non-nuclear capacities by which ER modulate cellular behavior is essential to ultimately harnessing these processes for therapeutic gain in numerous disease contexts.

KW - Bone mineralization

KW - Caveolae

KW - Endothelium

KW - Estrogen receptor

KW - Nitric oxide synthase

KW - Vascular smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=84895546872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895546872&partnerID=8YFLogxK

U2 - 10.1016/j.steroids.2013.11.002

DO - 10.1016/j.steroids.2013.11.002

M3 - Article

C2 - 24252382

AN - SCOPUS:84895546872

VL - 81

SP - 64

EP - 69

JO - Steroids

JF - Steroids

SN - 0039-128X

ER -