Recent insights into the biology of Barrett's esophagus

Henry Badgery, Lynn Chong, Elhadi Iich, Qin Huang, Smitha Rose Georgy, David H. Wang, Matthew Read

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosis. Our understanding of the pathogenesis and Barrett's metaplasia is incomplete, and this has limited the development of new therapeutic targets and agents, risk stratification ability, and management strategies. This review outlines current insights into the biology of BE and addresses controversies surrounding cell of origin, cellular reprogramming theories, updates on esophageal epithelial barrier function, and the significance of goblet cell metaplasia and its association with malignant change. Further research into the basic biology of BE is vital as it will underpin novel therapies and improve our ability to predict malignant progression and help identify the minority of patients who will develop EAC.

Original languageEnglish (US)
Pages (from-to)198-209
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume1481
Issue number1
DOIs
StatePublished - Nov 10 2020

Keywords

  • Barrett's esophagus
  • epithelial barrier function
  • esophageal adenocarcinoma
  • molecular reprogramming
  • signaling pathways

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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