Recent progress in metal-based nanoparticles mediated photodynamic therapy

Jingyao Sun; Semen Kormakov; Ying Liu; Yao Huang; Daming Wu; Zhaogang Yang

doi:10.3390/molecules23071704

Recent progress in metal-based nanoparticles mediated photodynamic therapy

Jingyao Sun, Semen Kormakov, Ying Liu, Yao Huang, Daming Wu, Zhaogang Yang

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

Original language	English (US)
Article number	1704
Journal	Molecules
Volume	23
Issue number	7
DOIs	https://doi.org/10.3390/molecules23071704
State	Published - 2018
Externally published	Yes

Keywords

Metal-based nanoparticles
Photodynamic therapy
Potential toxicity

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.3390/molecules23071704

Cite this

@article{0c3cc6f965fa4272b9c67b23911e2264,

title = "Recent progress in metal-based nanoparticles mediated photodynamic therapy",

abstract = "Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.",

keywords = "Metal-based nanoparticles, Photodynamic therapy, Potential toxicity",

author = "Jingyao Sun and Semen Kormakov and Ying Liu and Yao Huang and Daming Wu and Zhaogang Yang",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 51673020 and No. 51173015). Publisher Copyright: {\textcopyright} 2018 by the authors.",

year = "2018",

doi = "10.3390/molecules23071704",

language = "English (US)",

volume = "23",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Recent progress in metal-based nanoparticles mediated photodynamic therapy

AU - Sun, Jingyao

AU - Kormakov, Semen

AU - Liu, Ying

AU - Huang, Yao

AU - Wu, Daming

AU - Yang, Zhaogang

PY - 2018

Y1 - 2018

N2 - Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

AB - Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

KW - Metal-based nanoparticles

KW - Photodynamic therapy

KW - Potential toxicity

UR - http://www.scopus.com/inward/record.url?scp=85053626356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053626356&partnerID=8YFLogxK

U2 - 10.3390/molecules23071704

DO - 10.3390/molecules23071704

M3 - Review article

C2 - 30002333

AN - SCOPUS:85053626356

SN - 1420-3049

VL - 23

JO - Molecules

JF - Molecules

IS - 7

M1 - 1704

ER -

Recent progress in metal-based nanoparticles mediated photodynamic therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this