Recent progress in metal-based nanoparticles mediated photodynamic therapy

Jingyao Sun, Semen Kormakov, Ying Liu, Yao Huang, Daming Wu, Zhaogang Yang

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

Original languageEnglish (US)
Article number1704
JournalMolecules
Volume23
Issue number7
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Metal-based nanoparticles
  • Photodynamic therapy
  • Potential toxicity

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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