Recent progress in the treatment of cancer in children

Erin Butler, Kathleen Ludwig, Holly L. Pacenta, Laura J. Klesse, Tanya C. Watt, Theodore W. Laetsch

Research output: Contribution to journalReview articlepeer-review

Abstract

Although significant improvements have been made in the outcomes of children with cancer, the pace of improvement has slowed in recent years as the limits of therapy intensification may have been reached for many pediatric cancers. Furthermore, with increasing numbers of pediatric cancer survivors, the long-term side effects of treatment have become increasingly apparent. Therefore, attention has shifted to the use of molecularly targeted agents and immunotherapies to improve the outcomes of children who are not cured by traditional cytotoxic chemotherapies and to decrease exposure to cytotoxic chemotherapy and reduce late effects. This review describes the recent progress in the treatment of children with cancer, focusing in particular on diseases in which targeted and immunotherapeutic agents have made an impact.

Original languageEnglish (US)
Pages (from-to)315-332
Number of pages18
JournalCA Cancer Journal for Clinicians
Volume71
Issue number4
DOIs
StatePublished - Jul 1 2021
Externally publishedYes

Keywords

  • cancer of childhood
  • chemotherapy
  • clinical trials
  • pediatrics

ASJC Scopus subject areas

  • Hematology
  • Oncology

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