Recent total syntheses of anthraquinone-based natural products

Jackson A. Gartman, Uttam K. Tambar

Research output: Contribution to journalReview articlepeer-review

Abstract

The scientific community has found deep interest in anthraquinone-based compounds due to their therapeutic properties and challenging structural elements. Various architecturally beautiful natural products have been successfully synthesized in recent decades utilizing two main strategies: either an early-stage synthesis of the anthraquinone and further elongation of the system, or a late-stage introduction of the anthraquinone ring moiety. Select syntheses of complex anthraquinone monomers and dimers within the past 20 years are described with an emphasis on the retrosynthetic disconnections that shape the anthraquinone-installation strategy.

Original languageEnglish (US)
Article number132501
JournalTetrahedron
Volume105
DOIs
StatePublished - Jan 22 2022
Externally publishedYes

Keywords

  • Annulation
  • Anthraquinones
  • Cyclization
  • Cycloaddition
  • Natural products
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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