Receptor-mediated delivery of photoprotective agents by low-density lipoprotein

Stephen T. Mosley, Yuh Lin Yang, J. R. Falck, Richard G W Anderson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Low density lipoprotein (LDL) has been used to deliver toxic molecules to cells by receptor-mediated endocytosis. In these studies, the cholesteryl ester core of LDL was replaced with a lipophilic, toxic molecule. We now report that photoprotective azo dyes can be stably incorporated into LDL, and that this reconstituted LDL protects cells from the photosensitizing action of pyrene methanol (PM) in a receptor-dependent process. The photoprotective action of the azo dye is due to its ability to scavenge singlet oxygen that is produced by the photosensitive agent in response to UV light.

Original languageEnglish (US)
Pages (from-to)389-396
Number of pages8
JournalExperimental Cell Research
Volume155
Issue number2
DOIs
StatePublished - Dec 1984

ASJC Scopus subject areas

  • Cell Biology

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