Receptor-mediated delivery of photoprotective agents by low-density lipoprotein

Stephen T. Mosley; Yuh Lin Yang; J. R. Falck; Richard G W Anderson

doi:10.1016/0014-4827(84)90199-X

Receptor-mediated delivery of photoprotective agents by low-density lipoprotein

Stephen T. Mosley, Yuh Lin Yang, J. R. Falck, Richard G W Anderson

Biochemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Low density lipoprotein (LDL) has been used to deliver toxic molecules to cells by receptor-mediated endocytosis. In these studies, the cholesteryl ester core of LDL was replaced with a lipophilic, toxic molecule. We now report that photoprotective azo dyes can be stably incorporated into LDL, and that this reconstituted LDL protects cells from the photosensitizing action of pyrene methanol (PM) in a receptor-dependent process. The photoprotective action of the azo dye is due to its ability to scavenge singlet oxygen that is produced by the photosensitive agent in response to UV light.

Original language	English (US)
Pages (from-to)	389-396
Number of pages	8
Journal	Experimental Cell Research
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(84)90199-X
State	Published - Dec 1984

ASJC Scopus subject areas

Cell Biology

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title = "Receptor-mediated delivery of photoprotective agents by low-density lipoprotein",

abstract = "Low density lipoprotein (LDL) has been used to deliver toxic molecules to cells by receptor-mediated endocytosis. In these studies, the cholesteryl ester core of LDL was replaced with a lipophilic, toxic molecule. We now report that photoprotective azo dyes can be stably incorporated into LDL, and that this reconstituted LDL protects cells from the photosensitizing action of pyrene methanol (PM) in a receptor-dependent process. The photoprotective action of the azo dye is due to its ability to scavenge singlet oxygen that is produced by the photosensitive agent in response to UV light.",

author = "Mosley, {Stephen T.} and Yang, {Yuh Lin} and Falck, {J. R.} and Anderson, {Richard G W}",

note = "Funding Information: This work was supportedb y USPHS NIH Research Grant HL-20948a nd by a grant-in-aidf rom the American Heart Association with funds contributedi n part by the Texas affiliate.",

year = "1984",

month = dec,

doi = "10.1016/0014-4827(84)90199-X",

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pages = "389--396",

journal = "Experimental Cell Research",

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T1 - Receptor-mediated delivery of photoprotective agents by low-density lipoprotein

AU - Mosley, Stephen T.

AU - Yang, Yuh Lin

AU - Falck, J. R.

AU - Anderson, Richard G W

N1 - Funding Information: This work was supportedb y USPHS NIH Research Grant HL-20948a nd by a grant-in-aidf rom the American Heart Association with funds contributedi n part by the Texas affiliate.

PY - 1984/12

Y1 - 1984/12

N2 - Low density lipoprotein (LDL) has been used to deliver toxic molecules to cells by receptor-mediated endocytosis. In these studies, the cholesteryl ester core of LDL was replaced with a lipophilic, toxic molecule. We now report that photoprotective azo dyes can be stably incorporated into LDL, and that this reconstituted LDL protects cells from the photosensitizing action of pyrene methanol (PM) in a receptor-dependent process. The photoprotective action of the azo dye is due to its ability to scavenge singlet oxygen that is produced by the photosensitive agent in response to UV light.

AB - Low density lipoprotein (LDL) has been used to deliver toxic molecules to cells by receptor-mediated endocytosis. In these studies, the cholesteryl ester core of LDL was replaced with a lipophilic, toxic molecule. We now report that photoprotective azo dyes can be stably incorporated into LDL, and that this reconstituted LDL protects cells from the photosensitizing action of pyrene methanol (PM) in a receptor-dependent process. The photoprotective action of the azo dye is due to its ability to scavenge singlet oxygen that is produced by the photosensitive agent in response to UV light.

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Receptor-mediated delivery of photoprotective agents by low-density lipoprotein

Abstract

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