Receptor modifications in Hedgehog regulation

Qing Shi, Jin Jiang

Research output: Contribution to journalArticle

Abstract

The Hedgehog (Hh) signaling pathway is one of the highly conserved signaling cascades that control cell growth, cell fate, and pattern formation in species ranging from Drosophila to human. Smoothened (Smo), a G-proteincoupled- receptor (GPCR) family protein, serves as a core component to tranduce Hh signal across the cell membrane. Studying how the activity of Smo is regulated is a key to understand how Hh morphegen gradiant differentially induces target gene expression during normal animal development as well as how abnormal Hh signaling activity contributes to various human diseases. In this chapter, we focus on the regulation of Smo by its posttranslational modifications. By reviewing our current knowledge on how Hh ligands dynamically induce phosphorylation and ubiquitination of Smo and how these modifications coordinatedly modulate Smo function and downstream signaling events, we hope to inspire future exploration of comprehensive mechanisms underlying the regulation of Smo.

Original languageEnglish (US)
Pages (from-to)109-125
Number of pages17
JournalTopics in Medicinal Chemistry
Volume16
DOIs
StatePublished - 2015

Keywords

  • Hedgehog
  • Phospohrylation
  • Posttranslational modification
  • Smo
  • Smo binding proteins
  • Ubiquitination

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

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