Receptor modifications in Hedgehog regulation

Qing Shi, Jin Jiang

Research output: Contribution to journalArticle

Abstract

The Hedgehog (Hh) signaling pathway is one of the highly conserved signaling cascades that control cell growth, cell fate, and pattern formation in species ranging from Drosophila to human. Smoothened (Smo), a G-proteincoupled- receptor (GPCR) family protein, serves as a core component to tranduce Hh signal across the cell membrane. Studying how the activity of Smo is regulated is a key to understand how Hh morphegen gradiant differentially induces target gene expression during normal animal development as well as how abnormal Hh signaling activity contributes to various human diseases. In this chapter, we focus on the regulation of Smo by its posttranslational modifications. By reviewing our current knowledge on how Hh ligands dynamically induce phosphorylation and ubiquitination of Smo and how these modifications coordinatedly modulate Smo function and downstream signaling events, we hope to inspire future exploration of comprehensive mechanisms underlying the regulation of Smo.

Original languageEnglish (US)
Pages (from-to)109-125
Number of pages17
JournalTopics in Medicinal Chemistry
Volume16
DOIs
StatePublished - 2015

Fingerprint

Hedgehogs
Ubiquitination
Post Translational Protein Processing
Drosophila
Phosphorylation
Cell Membrane
Ligands
Gene Expression
Growth
Proteins

Keywords

  • Hedgehog
  • Phospohrylation
  • Posttranslational modification
  • Smo
  • Smo binding proteins
  • Ubiquitination

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Receptor modifications in Hedgehog regulation. / Shi, Qing; Jiang, Jin.

In: Topics in Medicinal Chemistry, Vol. 16, 2015, p. 109-125.

Research output: Contribution to journalArticle

@article{7b63d30e91f74c9eb55a93c8b5cb030b,
title = "Receptor modifications in Hedgehog regulation",
abstract = "The Hedgehog (Hh) signaling pathway is one of the highly conserved signaling cascades that control cell growth, cell fate, and pattern formation in species ranging from Drosophila to human. Smoothened (Smo), a G-proteincoupled- receptor (GPCR) family protein, serves as a core component to tranduce Hh signal across the cell membrane. Studying how the activity of Smo is regulated is a key to understand how Hh morphegen gradiant differentially induces target gene expression during normal animal development as well as how abnormal Hh signaling activity contributes to various human diseases. In this chapter, we focus on the regulation of Smo by its posttranslational modifications. By reviewing our current knowledge on how Hh ligands dynamically induce phosphorylation and ubiquitination of Smo and how these modifications coordinatedly modulate Smo function and downstream signaling events, we hope to inspire future exploration of comprehensive mechanisms underlying the regulation of Smo.",
keywords = "Hedgehog, Phospohrylation, Posttranslational modification, Smo, Smo binding proteins, Ubiquitination",
author = "Qing Shi and Jin Jiang",
year = "2015",
doi = "10.1007/7355_2014_62",
language = "English (US)",
volume = "16",
pages = "109--125",
journal = "Topics in Medicinal Chemistry",
issn = "1862-2461",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Receptor modifications in Hedgehog regulation

AU - Shi, Qing

AU - Jiang, Jin

PY - 2015

Y1 - 2015

N2 - The Hedgehog (Hh) signaling pathway is one of the highly conserved signaling cascades that control cell growth, cell fate, and pattern formation in species ranging from Drosophila to human. Smoothened (Smo), a G-proteincoupled- receptor (GPCR) family protein, serves as a core component to tranduce Hh signal across the cell membrane. Studying how the activity of Smo is regulated is a key to understand how Hh morphegen gradiant differentially induces target gene expression during normal animal development as well as how abnormal Hh signaling activity contributes to various human diseases. In this chapter, we focus on the regulation of Smo by its posttranslational modifications. By reviewing our current knowledge on how Hh ligands dynamically induce phosphorylation and ubiquitination of Smo and how these modifications coordinatedly modulate Smo function and downstream signaling events, we hope to inspire future exploration of comprehensive mechanisms underlying the regulation of Smo.

AB - The Hedgehog (Hh) signaling pathway is one of the highly conserved signaling cascades that control cell growth, cell fate, and pattern formation in species ranging from Drosophila to human. Smoothened (Smo), a G-proteincoupled- receptor (GPCR) family protein, serves as a core component to tranduce Hh signal across the cell membrane. Studying how the activity of Smo is regulated is a key to understand how Hh morphegen gradiant differentially induces target gene expression during normal animal development as well as how abnormal Hh signaling activity contributes to various human diseases. In this chapter, we focus on the regulation of Smo by its posttranslational modifications. By reviewing our current knowledge on how Hh ligands dynamically induce phosphorylation and ubiquitination of Smo and how these modifications coordinatedly modulate Smo function and downstream signaling events, we hope to inspire future exploration of comprehensive mechanisms underlying the regulation of Smo.

KW - Hedgehog

KW - Phospohrylation

KW - Posttranslational modification

KW - Smo

KW - Smo binding proteins

KW - Ubiquitination

UR - http://www.scopus.com/inward/record.url?scp=84934289799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934289799&partnerID=8YFLogxK

U2 - 10.1007/7355_2014_62

DO - 10.1007/7355_2014_62

M3 - Article

AN - SCOPUS:84934289799

VL - 16

SP - 109

EP - 125

JO - Topics in Medicinal Chemistry

JF - Topics in Medicinal Chemistry

SN - 1862-2461

ER -