Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness

L. W K Chung, M. E. Gleave, J. T. Hsieh, S. J. Hong, H. E. Zhau

Research output: Contribution to journalArticle

87 Scopus citations


A novel cell-cell recombination model was established to test the reciprocal mesenchymal (fibroblast)-epithelial interaction in the prostate gland. Both growth factors and ECM pathways were found to be actively engaged during cellular communications. The application of this cell-cell recombination concept to prostate cancer established a new human prostate cancer animal model in which the tumours actively secrete prostate specific antigen, a known human prostate cancer marker. This review explores the significance of mesenchymal-epithelial interaction in determining prostate hormonal responsiveness and prostate cell transformation and speculates on the potential roles of mesenchymal-epithelial interaction in prostate cancer growth and progression.

Original languageEnglish (US)
Pages (from-to)91-121
Number of pages31
JournalCancer Surveys
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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