RecO is essential for DNA damage repair in Deinococcus radiodurans

Guangzhi Xu, Liangyan Wang, Huan Chen, Huiming Lu, Nanjiao Ying, Bing Tian, Yuejin Hua

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Here we present direct evidence for the vital role of RecO in Deinococcus radioduran's radioresistance. A recO null mutant was constructed using a deletion replacement method. The mutant exhibited a growth defect and extreme sensitivity to irradiation with gamma rays and UV light. These results suggest that DNA repair in this organism occurs mainly via the RecF pathway.

Original languageEnglish (US)
Pages (from-to)2624-2628
Number of pages5
JournalJournal of bacteriology
Volume190
Issue number7
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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    Xu, G., Wang, L., Chen, H., Lu, H., Ying, N., Tian, B., & Hua, Y. (2008). RecO is essential for DNA damage repair in Deinococcus radiodurans. Journal of bacteriology, 190(7), 2624-2628. https://doi.org/10.1128/JB.01851-07