Recommendations for the use of botulinum toxin type A in the management of cerebral palsy

H. Kerr Graham, K. Roger Aoki, Ilona Autti-Rämö, Roslyn N. Boyd, Mauricio R. Delgado, Deborah J. Gaebler-Spira, Mark E. Gormley, Barry M. Guyer, Florian Heinen, Andrew F. Holton, Dennis Matthews, Guy Molenaers, Francesco Motta, Pedro J. García Ruiz, Jörg Wissel

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

Botulinum toxin type A (BTX-A) is increasingly being used for the treatment of childhood spasticity, particularly cerebral palsy. However, until very recently, all such use in this indication has been unapproved with no generally accepted treatment protocols, resulting in considerable uncertainty and variation in its use as a therapeutic agent. In view of the increasing awareness of, and interest in, this approach to the treatment of spasticity, and also the recent licensing in a number of countries of a BTX-A preparation for treating equinus deformity in children, it would seem timely to establish a framework of guidelines for the safe and efficacious use of BTX-A for treating spasticity in children. This paper represents an attempt, by a group of 15 experienced clinicians and scientists from a variety of disciplines, to arrive at a consensus and produce detailed recommendations as to appropriate patient selection and assessment, dosage, injection technique and outcome measurement. The importance of adjunctive physiotherapy, orthoses and casting is also stressed. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalGait and Posture
Volume11
Issue number1
DOIs
StatePublished - Feb 2000

Fingerprint

Type A Botulinum Toxins
Cerebral Palsy
Equinus Deformity
Orthotic Devices
Licensure
Clinical Protocols
Patient Selection
Uncertainty
Therapeutics
Guidelines
Injections

Keywords

  • BOTOX®
  • Botulinum toxin type A
  • Cerebral palsy
  • Consensus document
  • Guidelines

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Graham, H. K., Aoki, K. R., Autti-Rämö, I., Boyd, R. N., Delgado, M. R., Gaebler-Spira, D. J., ... Wissel, J. (2000). Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. Gait and Posture, 11(1), 67-79. https://doi.org/10.1016/S0966-6362(99)00054-5

Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. / Graham, H. Kerr; Aoki, K. Roger; Autti-Rämö, Ilona; Boyd, Roslyn N.; Delgado, Mauricio R.; Gaebler-Spira, Deborah J.; Gormley, Mark E.; Guyer, Barry M.; Heinen, Florian; Holton, Andrew F.; Matthews, Dennis; Molenaers, Guy; Motta, Francesco; García Ruiz, Pedro J.; Wissel, Jörg.

In: Gait and Posture, Vol. 11, No. 1, 02.2000, p. 67-79.

Research output: Contribution to journalArticle

Graham, HK, Aoki, KR, Autti-Rämö, I, Boyd, RN, Delgado, MR, Gaebler-Spira, DJ, Gormley, ME, Guyer, BM, Heinen, F, Holton, AF, Matthews, D, Molenaers, G, Motta, F, García Ruiz, PJ & Wissel, J 2000, 'Recommendations for the use of botulinum toxin type A in the management of cerebral palsy', Gait and Posture, vol. 11, no. 1, pp. 67-79. https://doi.org/10.1016/S0966-6362(99)00054-5
Graham, H. Kerr ; Aoki, K. Roger ; Autti-Rämö, Ilona ; Boyd, Roslyn N. ; Delgado, Mauricio R. ; Gaebler-Spira, Deborah J. ; Gormley, Mark E. ; Guyer, Barry M. ; Heinen, Florian ; Holton, Andrew F. ; Matthews, Dennis ; Molenaers, Guy ; Motta, Francesco ; García Ruiz, Pedro J. ; Wissel, Jörg. / Recommendations for the use of botulinum toxin type A in the management of cerebral palsy. In: Gait and Posture. 2000 ; Vol. 11, No. 1. pp. 67-79.
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