Reconstitution and characterization of a calcium-activated channel from heart

Joseph A Hill, R. Coronado, H. C. Strauss

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

This paper is the first description of a calcium-activated nonspecific cation channel in adult ventricular muscle. We report gating kinetics and ionic selectivity data from experiments performed at the single channel level. Calcium activation is described by a gating model wherein two ions are involved in the reaction. Channel gating exhibited marked voltage dependence. Ionic selectivity experiments indicated that the channel is cation-selective but unable to discriminate between Na+ and K+. We discuss evidence that this channel mediates transient inward current in ventricular tissue; thus, the channel may be involved in afterdepolarization-induced cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalCirculation research
Volume62
Issue number2
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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