Abstract
This paper is the first description of a calcium-activated nonspecific cation channel in adult ventricular muscle. We report gating kinetics and ionic selectivity data from experiments performed at the single channel level. Calcium activation is described by a gating model wherein two ions are involved in the reaction. Channel gating exhibited marked voltage dependence. Ionic selectivity experiments indicated that the channel is cation-selective but unable to discriminate between Na+ and K+. We discuss evidence that this channel mediates transient inward current in ventricular tissue; thus, the channel may be involved in afterdepolarization-induced cardiac arrhythmias.
Original language | English (US) |
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Pages (from-to) | 411-415 |
Number of pages | 5 |
Journal | Circulation research |
Volume | 62 |
Issue number | 2 |
DOIs | |
State | Published - 1988 |
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine