Reconstitution of ionic channels from human heart

Joseph A Hill, Roberto Coronado, Harold C. Strauss

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

This report is the first description of single ion channels from human myocardium. Using explanted human left ventricular tissue, we have studied three K-conducting and two anion-conducting channels. We report our observations of gating and ionic selectivity properties of these channels which, we argue, derive from both sarcolemmal and sarcoplasmic reticulum membranes. We postulate that one channel is the K-conducting channel (SR K channel) from human cardiac sarcoplasmic reticulum. Another channel is similar to a dimeric Cl- channel from Torpedo electroplax, displaying two equally spaced levels of open state conductance.

Original languageEnglish (US)
Pages (from-to)315-322
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume21
Issue number3
DOIs
StatePublished - Mar 1989

Keywords

  • Anion-conducting channels
  • Gating
  • Ion selectivity
  • K-conducting channels

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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