Recovery from rapidly progressive glomerulonephritis. Improvement after plasmapheresis and immunosuppression

S. E. Warren, J. A. Mitas, S. M. Golbus, A. R. Swerdlin, I. M. Cohen, R. E. Cronin

Research output: Contribution to journalArticle

Abstract

Two patients with rapidly advancing renal insufficiency underwent biopsy and were found to have crescentic glomerulonephritis. Patient 1 demonstrated findings compatible with Goodpasture's syndrome. Crescents were present in 100% of his glomeruli. Patient 2 had findings of immune complex-mediated glomerulonephritis and crescents in greater than 90% of his glomeruli. Both patients were treated with high-dose prednisone, cyclophosphamide, and plasmapheresis. Patient 2 additionally required hemodialysis for a brief period. Renal function improved in both patients and has not deteriorated after follow-up of 14 and 18 months, respectively. Repeated renal biopsies were performed in each patient. Our findings suggest that clinical improvement and histologic healing are possible in rapidly progressive glomerulonephritis despite the initial presence of crescents in every glomerulus.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalArchives of Internal Medicine
Volume141
Issue number2
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Internal Medicine

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    Warren, S. E., Mitas, J. A., Golbus, S. M., Swerdlin, A. R., Cohen, I. M., & Cronin, R. E. (1981). Recovery from rapidly progressive glomerulonephritis. Improvement after plasmapheresis and immunosuppression. Archives of Internal Medicine, 141(2), 175-180. https://doi.org/10.1001/archinte.141.2.175