Recovery From Rapidly Progressive Glomerulonephritis Improvement After Plasmapheresis and Immunosuppression

Sanford E. Warren, John A. Mitas, Steven M. Golbus, Aron R. Swerdlin, Irving M. Cohen, Robert E. Cronin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Two patients with rapidly advancing renal insufficiency underwent biopsy and were found to have crescentic glomerulonephritis. Patient 1 demonstrated findings compatible with Goodpasture's syndrome. Crescents were present in 100% of his glomeruli. Patient 2 had findings of immune complex-mediated glomerulonephritis and crescents in greater than 90% of his glomeruli. Both patients were treated with high-dose prednisone, cyclophosphamide, and plasmapheresis. Patient 2 additionally required hemodialysis for a brief period. Renal function improved in both patients and has not deteriorated after followup of 14 and 18 months, respectively. Repeated renal biopsies were performed in each patient. Our findings suggest that clinical improvement and histologic healing are possible in rapidly progressive glomerulonephritis despite the initial presence of crescents in every glomerulus.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalArchives of Internal Medicine
Volume141
Issue number2
DOIs
StatePublished - 1981

Fingerprint

Plasmapheresis
Glomerulonephritis
Immunosuppression
Anti-Glomerular Basement Membrane Disease
Kidney
Biopsy
Prednisone
Antigen-Antibody Complex
Cyclophosphamide
Renal Insufficiency
Renal Dialysis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Recovery From Rapidly Progressive Glomerulonephritis Improvement After Plasmapheresis and Immunosuppression. / Warren, Sanford E.; Mitas, John A.; Golbus, Steven M.; Swerdlin, Aron R.; Cohen, Irving M.; Cronin, Robert E.

In: Archives of Internal Medicine, Vol. 141, No. 2, 1981, p. 175-180.

Research output: Contribution to journalArticle

Warren, Sanford E. ; Mitas, John A. ; Golbus, Steven M. ; Swerdlin, Aron R. ; Cohen, Irving M. ; Cronin, Robert E. / Recovery From Rapidly Progressive Glomerulonephritis Improvement After Plasmapheresis and Immunosuppression. In: Archives of Internal Medicine. 1981 ; Vol. 141, No. 2. pp. 175-180.
@article{3f9702e7f6c44a8c99028e7c4077c67a,
title = "Recovery From Rapidly Progressive Glomerulonephritis Improvement After Plasmapheresis and Immunosuppression",
abstract = "Two patients with rapidly advancing renal insufficiency underwent biopsy and were found to have crescentic glomerulonephritis. Patient 1 demonstrated findings compatible with Goodpasture's syndrome. Crescents were present in 100{\%} of his glomeruli. Patient 2 had findings of immune complex-mediated glomerulonephritis and crescents in greater than 90{\%} of his glomeruli. Both patients were treated with high-dose prednisone, cyclophosphamide, and plasmapheresis. Patient 2 additionally required hemodialysis for a brief period. Renal function improved in both patients and has not deteriorated after followup of 14 and 18 months, respectively. Repeated renal biopsies were performed in each patient. Our findings suggest that clinical improvement and histologic healing are possible in rapidly progressive glomerulonephritis despite the initial presence of crescents in every glomerulus.",
author = "Warren, {Sanford E.} and Mitas, {John A.} and Golbus, {Steven M.} and Swerdlin, {Aron R.} and Cohen, {Irving M.} and Cronin, {Robert E.}",
year = "1981",
doi = "10.1001/archinte.1981.00340020037014",
language = "English (US)",
volume = "141",
pages = "175--180",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Recovery From Rapidly Progressive Glomerulonephritis Improvement After Plasmapheresis and Immunosuppression

AU - Warren, Sanford E.

AU - Mitas, John A.

AU - Golbus, Steven M.

AU - Swerdlin, Aron R.

AU - Cohen, Irving M.

AU - Cronin, Robert E.

PY - 1981

Y1 - 1981

N2 - Two patients with rapidly advancing renal insufficiency underwent biopsy and were found to have crescentic glomerulonephritis. Patient 1 demonstrated findings compatible with Goodpasture's syndrome. Crescents were present in 100% of his glomeruli. Patient 2 had findings of immune complex-mediated glomerulonephritis and crescents in greater than 90% of his glomeruli. Both patients were treated with high-dose prednisone, cyclophosphamide, and plasmapheresis. Patient 2 additionally required hemodialysis for a brief period. Renal function improved in both patients and has not deteriorated after followup of 14 and 18 months, respectively. Repeated renal biopsies were performed in each patient. Our findings suggest that clinical improvement and histologic healing are possible in rapidly progressive glomerulonephritis despite the initial presence of crescents in every glomerulus.

AB - Two patients with rapidly advancing renal insufficiency underwent biopsy and were found to have crescentic glomerulonephritis. Patient 1 demonstrated findings compatible with Goodpasture's syndrome. Crescents were present in 100% of his glomeruli. Patient 2 had findings of immune complex-mediated glomerulonephritis and crescents in greater than 90% of his glomeruli. Both patients were treated with high-dose prednisone, cyclophosphamide, and plasmapheresis. Patient 2 additionally required hemodialysis for a brief period. Renal function improved in both patients and has not deteriorated after followup of 14 and 18 months, respectively. Repeated renal biopsies were performed in each patient. Our findings suggest that clinical improvement and histologic healing are possible in rapidly progressive glomerulonephritis despite the initial presence of crescents in every glomerulus.

UR - http://www.scopus.com/inward/record.url?scp=84948011482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948011482&partnerID=8YFLogxK

U2 - 10.1001/archinte.1981.00340020037014

DO - 10.1001/archinte.1981.00340020037014

M3 - Article

AN - SCOPUS:84948011482

VL - 141

SP - 175

EP - 180

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 2

ER -