Recovery of heart function in children with acute severe heart failure

John J. O'Sullivan, Susan L. Roche, David S. Crossland, Milind P. Chaudhari, Richard C. Kirk, Hasan Asif

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

BACKGROUND. The prognosis of acute heart failure is such that many children are considered for transplantation. Recovery of severe heart failure in a proportion of patients diagnosed with either dilated cardiomyopathy or myocarditis is well recognized, and this complicates the assessment for transplantation. There is little data on the time scale of recovery of heart function in children. OBJECTIVES. To describe the time course over which echocardiographic improvement of systolic function occurred in a cohort of children who presented in acute heart failure, without structural or metabolic abnormality. METHODS. Children with a first presentation of acute severe heart failure between 1990 and 2005. Time from presentation to the echocardiogram before left ventricular fractional shortening (FS) improved to 20% and 30% (complete recovery) was recorded. RESULTS. Twenty-seven children (11 male) were identified, and all had an initial FS <15%. Twenty-one patients required intravenous inotropes and three patients required extracorporeal membrane oxygenation. Seven patients had been on the active transplant list for a mean duration of 155 days. Four patients had probable viral myocarditis. Mean age at presentation was 15.7 (range, 0.1-72) months. Mean time to an FS of 20% was 3.6 (0.2-18) months and to 30% was 8.9 (0.7-24) months. Complete recovery occurred within 6, 9, 12, 18, and 24 months of presentation in 44%, 55%, 66%, and 96%, respectively. There was no correlation between age of presentation and length of time to recovery. CONCLUSIONS. Complete recovery of left ventricular systolic function is often delayed to more than 1 year from presentation. This may have major implications for timing of transplantation in an era where prolonged mechanical cardiac support is feasible even in infants.

Original languageEnglish (US)
Pages (from-to)975-979
Number of pages5
JournalTransplantation
Volume85
Issue number7
DOIs
StatePublished - Apr 1 2008

Fingerprint

Recovery of Function
Heart Failure
Transplantation
Myocarditis
Extracorporeal Membrane Oxygenation
Dilated Cardiomyopathy
Left Ventricular Function
Transplants

Keywords

  • Children
  • Dilated cardiomyopathy
  • Listing for transplantation
  • Myocarditis

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

O'Sullivan, J. J., Roche, S. L., Crossland, D. S., Chaudhari, M. P., Kirk, R. C., & Asif, H. (2008). Recovery of heart function in children with acute severe heart failure. Transplantation, 85(7), 975-979. https://doi.org/10.1097/TP.0b013e318168fe3c

Recovery of heart function in children with acute severe heart failure. / O'Sullivan, John J.; Roche, Susan L.; Crossland, David S.; Chaudhari, Milind P.; Kirk, Richard C.; Asif, Hasan.

In: Transplantation, Vol. 85, No. 7, 01.04.2008, p. 975-979.

Research output: Contribution to journalArticle

O'Sullivan, JJ, Roche, SL, Crossland, DS, Chaudhari, MP, Kirk, RC & Asif, H 2008, 'Recovery of heart function in children with acute severe heart failure', Transplantation, vol. 85, no. 7, pp. 975-979. https://doi.org/10.1097/TP.0b013e318168fe3c
O'Sullivan JJ, Roche SL, Crossland DS, Chaudhari MP, Kirk RC, Asif H. Recovery of heart function in children with acute severe heart failure. Transplantation. 2008 Apr 1;85(7):975-979. https://doi.org/10.1097/TP.0b013e318168fe3c
O'Sullivan, John J. ; Roche, Susan L. ; Crossland, David S. ; Chaudhari, Milind P. ; Kirk, Richard C. ; Asif, Hasan. / Recovery of heart function in children with acute severe heart failure. In: Transplantation. 2008 ; Vol. 85, No. 7. pp. 975-979.
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abstract = "BACKGROUND. The prognosis of acute heart failure is such that many children are considered for transplantation. Recovery of severe heart failure in a proportion of patients diagnosed with either dilated cardiomyopathy or myocarditis is well recognized, and this complicates the assessment for transplantation. There is little data on the time scale of recovery of heart function in children. OBJECTIVES. To describe the time course over which echocardiographic improvement of systolic function occurred in a cohort of children who presented in acute heart failure, without structural or metabolic abnormality. METHODS. Children with a first presentation of acute severe heart failure between 1990 and 2005. Time from presentation to the echocardiogram before left ventricular fractional shortening (FS) improved to 20{\%} and 30{\%} (complete recovery) was recorded. RESULTS. Twenty-seven children (11 male) were identified, and all had an initial FS <15{\%}. Twenty-one patients required intravenous inotropes and three patients required extracorporeal membrane oxygenation. Seven patients had been on the active transplant list for a mean duration of 155 days. Four patients had probable viral myocarditis. Mean age at presentation was 15.7 (range, 0.1-72) months. Mean time to an FS of 20{\%} was 3.6 (0.2-18) months and to 30{\%} was 8.9 (0.7-24) months. Complete recovery occurred within 6, 9, 12, 18, and 24 months of presentation in 44{\%}, 55{\%}, 66{\%}, and 96{\%}, respectively. There was no correlation between age of presentation and length of time to recovery. CONCLUSIONS. Complete recovery of left ventricular systolic function is often delayed to more than 1 year from presentation. This may have major implications for timing of transplantation in an era where prolonged mechanical cardiac support is feasible even in infants.",
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AU - Roche, Susan L.

AU - Crossland, David S.

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AU - Kirk, Richard C.

AU - Asif, Hasan

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N2 - BACKGROUND. The prognosis of acute heart failure is such that many children are considered for transplantation. Recovery of severe heart failure in a proportion of patients diagnosed with either dilated cardiomyopathy or myocarditis is well recognized, and this complicates the assessment for transplantation. There is little data on the time scale of recovery of heart function in children. OBJECTIVES. To describe the time course over which echocardiographic improvement of systolic function occurred in a cohort of children who presented in acute heart failure, without structural or metabolic abnormality. METHODS. Children with a first presentation of acute severe heart failure between 1990 and 2005. Time from presentation to the echocardiogram before left ventricular fractional shortening (FS) improved to 20% and 30% (complete recovery) was recorded. RESULTS. Twenty-seven children (11 male) were identified, and all had an initial FS <15%. Twenty-one patients required intravenous inotropes and three patients required extracorporeal membrane oxygenation. Seven patients had been on the active transplant list for a mean duration of 155 days. Four patients had probable viral myocarditis. Mean age at presentation was 15.7 (range, 0.1-72) months. Mean time to an FS of 20% was 3.6 (0.2-18) months and to 30% was 8.9 (0.7-24) months. Complete recovery occurred within 6, 9, 12, 18, and 24 months of presentation in 44%, 55%, 66%, and 96%, respectively. There was no correlation between age of presentation and length of time to recovery. CONCLUSIONS. Complete recovery of left ventricular systolic function is often delayed to more than 1 year from presentation. This may have major implications for timing of transplantation in an era where prolonged mechanical cardiac support is feasible even in infants.

AB - BACKGROUND. The prognosis of acute heart failure is such that many children are considered for transplantation. Recovery of severe heart failure in a proportion of patients diagnosed with either dilated cardiomyopathy or myocarditis is well recognized, and this complicates the assessment for transplantation. There is little data on the time scale of recovery of heart function in children. OBJECTIVES. To describe the time course over which echocardiographic improvement of systolic function occurred in a cohort of children who presented in acute heart failure, without structural or metabolic abnormality. METHODS. Children with a first presentation of acute severe heart failure between 1990 and 2005. Time from presentation to the echocardiogram before left ventricular fractional shortening (FS) improved to 20% and 30% (complete recovery) was recorded. RESULTS. Twenty-seven children (11 male) were identified, and all had an initial FS <15%. Twenty-one patients required intravenous inotropes and three patients required extracorporeal membrane oxygenation. Seven patients had been on the active transplant list for a mean duration of 155 days. Four patients had probable viral myocarditis. Mean age at presentation was 15.7 (range, 0.1-72) months. Mean time to an FS of 20% was 3.6 (0.2-18) months and to 30% was 8.9 (0.7-24) months. Complete recovery occurred within 6, 9, 12, 18, and 24 months of presentation in 44%, 55%, 66%, and 96%, respectively. There was no correlation between age of presentation and length of time to recovery. CONCLUSIONS. Complete recovery of left ventricular systolic function is often delayed to more than 1 year from presentation. This may have major implications for timing of transplantation in an era where prolonged mechanical cardiac support is feasible even in infants.

KW - Children

KW - Dilated cardiomyopathy

KW - Listing for transplantation

KW - Myocarditis

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