Abstract
We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 318-322 |
| Number of pages | 5 |
| Journal | Clinical Nephrology |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
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Keywords
- Acute kidney injury
- Cast nephropathy
- Hemodialysis
- High cut-off dialyzer
- Myeloma
- Theralite
ASJC Scopus subject areas
- Nephrology
Cite this
Recovery of kidney function following delayed use of theralite™ dialyzer in a patient with myeloma cast nephropathy. / Dahal, Khagendra; Shastri, Shani; Narayanasami, Uma; Bijol, Vanesa; Rider, Karen; Strom, James A.; Jaber, Bertrand L.
In: Clinical Nephrology, Vol. 79, No. 4, 04.2013, p. 318-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery of kidney function following delayed use of theralite™ dialyzer in a patient with myeloma cast nephropathy
AU - Dahal, Khagendra
AU - Shastri, Shani
AU - Narayanasami, Uma
AU - Bijol, Vanesa
AU - Rider, Karen
AU - Strom, James A.
AU - Jaber, Bertrand L.
PY - 2013/4
Y1 - 2013/4
N2 - We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
AB - We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
KW - Acute kidney injury
KW - Cast nephropathy
KW - Hemodialysis
KW - High cut-off dialyzer
KW - Myeloma
KW - Theralite
UR - http://www.scopus.com/inward/record.url?scp=84877318286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877318286&partnerID=8YFLogxK
U2 - 10.5414/CN107357
DO - 10.5414/CN107357
M3 - Article
C2 - 22541683
AN - SCOPUS:84877318286
VL - 79
SP - 318
EP - 322
JO - Clinical Nephrology
JF - Clinical Nephrology
SN - 0301-0430
IS - 4
ER -