Abstract
We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
Original language | English (US) |
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Pages (from-to) | 318-322 |
Number of pages | 5 |
Journal | Clinical Nephrology |
Volume | 79 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2013 |
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Keywords
- Acute kidney injury
- Cast nephropathy
- Hemodialysis
- High cut-off dialyzer
- Myeloma
- Theralite
ASJC Scopus subject areas
- Nephrology
Cite this
Recovery of kidney function following delayed use of theralite™ dialyzer in a patient with myeloma cast nephropathy. / Dahal, Khagendra; Shastri, Shani; Narayanasami, Uma; Bijol, Vanesa; Rider, Karen; Strom, James A.; Jaber, Bertrand L.
In: Clinical Nephrology, Vol. 79, No. 4, 04.2013, p. 318-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery of kidney function following delayed use of theralite™ dialyzer in a patient with myeloma cast nephropathy
AU - Dahal, Khagendra
AU - Shastri, Shani
AU - Narayanasami, Uma
AU - Bijol, Vanesa
AU - Rider, Karen
AU - Strom, James A.
AU - Jaber, Bertrand L.
PY - 2013/4
Y1 - 2013/4
N2 - We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
AB - We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
KW - Acute kidney injury
KW - Cast nephropathy
KW - Hemodialysis
KW - High cut-off dialyzer
KW - Myeloma
KW - Theralite
UR - http://www.scopus.com/inward/record.url?scp=84877318286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877318286&partnerID=8YFLogxK
U2 - 10.5414/CN107357
DO - 10.5414/CN107357
M3 - Article
C2 - 22541683
AN - SCOPUS:84877318286
VL - 79
SP - 318
EP - 322
JO - Clinical Nephrology
JF - Clinical Nephrology
SN - 0301-0430
IS - 4
ER -