Recruitment and retention of pregnant women into clinical research trials: An overview of challenges, facilitators, and best practices

Paula M. Frew, Diane S. Saint-Victor, Margaret Brewinski Isaacs, Sonnie Kim, Geeta K. Swamy, Jeanne S. Sheffield, Kathryn M. Edwards, Tonya Villafana, Ouda Kamagate, Kevin Ault

Research output: Contribution to journalReview article

54 Scopus citations

Abstract

Pregnant women are a vulnerable group who are needed in clinical research studies to advance prevention and treatment options for this population. Yet, pregnant women remain underrepresented in clinical research. Through the lens of the socioecological model, we highlight reported barriers and facilitators to recruitment and retention of pregnant women in studies that sought their participation. We trace historical, policy-based reasons for the exclusion of pregnant women in clinical studies to present-day rationale for inclusion of this group. The findings highlight why it has been difficult to recruit and retain this population over time. A body of literature suggests that integrative sampling and recruitment methods that leverage the influence and reach of prenatal providers will overcome recruitment challenges. We argue that these strategies, in combination with building strong engagement with existing community-based organizations, will enable teams to more effectively promote and retain pregnant women in future longitudinal cohort studies.

Original languageEnglish (US)
Pages (from-to)S400-S407
JournalClinical Infectious Diseases
Volume59
DOIs
StatePublished - 2014

Keywords

  • Clinical research trials
  • Pregnant women
  • Recruitment
  • Retention
  • Vulnerable populations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Recruitment and retention of pregnant women into clinical research trials: An overview of challenges, facilitators, and best practices'. Together they form a unique fingerprint.

  • Cite this

    Frew, P. M., Saint-Victor, D. S., Isaacs, M. B., Kim, S., Swamy, G. K., Sheffield, J. S., Edwards, K. M., Villafana, T., Kamagate, O., & Ault, K. (2014). Recruitment and retention of pregnant women into clinical research trials: An overview of challenges, facilitators, and best practices. Clinical Infectious Diseases, 59, S400-S407. https://doi.org/10.1093/cid/ciu726