Rectal radiation dose-reduction techniques in prostate cancer: A focus on the rectal spacer

Andrew J. Leiker, Neil B Desai, Michael R Folkert

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Prostate cancer is the most common cancer in men. External beam radiotherapy by a variety of methods is a standard treatment option with excellent disease control. However, acute and late rectal side effects remain a limiting concern in intensification of therapy in higher-risk patients and in efforts to reduce treatment burden in others. A number of techniques have emerged that allow for high-radiation dose delivery to the prostate with reduced risk of rectal toxicity, including image-guided intensity-modulated radiation therapy, endorectal balloons and various forms of rectal spacers. Image-guided radiation therapy, either intensity-modulated radiation therapy or stereotactic ablative radiation therapy, in conjunction with a rectal spacer, is an efficacious means to reduce acute and long-term rectal toxicity.

Original languageEnglish (US)
Pages (from-to)2773-2788
Number of pages16
JournalFuture Oncology
Volume14
Issue number26
DOIs
StatePublished - Nov 1 2018

Fingerprint

Prostatic Neoplasms
Radiotherapy
Radiation
Image-Guided Radiotherapy
Prostate
Therapeutics
Neoplasms

Keywords

  • endorectal balloon
  • erectile dysfunction
  • prostate cancer
  • radiation therapy
  • rectal spacer
  • rectal toxicity
  • stereotactic ablative radiotherapy
  • stereotactic body radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Rectal radiation dose-reduction techniques in prostate cancer : A focus on the rectal spacer. / Leiker, Andrew J.; Desai, Neil B; Folkert, Michael R.

In: Future Oncology, Vol. 14, No. 26, 01.11.2018, p. 2773-2788.

Research output: Contribution to journalReview article

@article{ddc1308030b74a98b9e621d7830e0290,
title = "Rectal radiation dose-reduction techniques in prostate cancer: A focus on the rectal spacer",
abstract = "Prostate cancer is the most common cancer in men. External beam radiotherapy by a variety of methods is a standard treatment option with excellent disease control. However, acute and late rectal side effects remain a limiting concern in intensification of therapy in higher-risk patients and in efforts to reduce treatment burden in others. A number of techniques have emerged that allow for high-radiation dose delivery to the prostate with reduced risk of rectal toxicity, including image-guided intensity-modulated radiation therapy, endorectal balloons and various forms of rectal spacers. Image-guided radiation therapy, either intensity-modulated radiation therapy or stereotactic ablative radiation therapy, in conjunction with a rectal spacer, is an efficacious means to reduce acute and long-term rectal toxicity.",
keywords = "endorectal balloon, erectile dysfunction, prostate cancer, radiation therapy, rectal spacer, rectal toxicity, stereotactic ablative radiotherapy, stereotactic body radiotherapy",
author = "Leiker, {Andrew J.} and Desai, {Neil B} and Folkert, {Michael R}",
year = "2018",
month = "11",
day = "1",
doi = "10.2217/fon-2018-0286",
language = "English (US)",
volume = "14",
pages = "2773--2788",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "26",

}

TY - JOUR

T1 - Rectal radiation dose-reduction techniques in prostate cancer

T2 - A focus on the rectal spacer

AU - Leiker, Andrew J.

AU - Desai, Neil B

AU - Folkert, Michael R

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Prostate cancer is the most common cancer in men. External beam radiotherapy by a variety of methods is a standard treatment option with excellent disease control. However, acute and late rectal side effects remain a limiting concern in intensification of therapy in higher-risk patients and in efforts to reduce treatment burden in others. A number of techniques have emerged that allow for high-radiation dose delivery to the prostate with reduced risk of rectal toxicity, including image-guided intensity-modulated radiation therapy, endorectal balloons and various forms of rectal spacers. Image-guided radiation therapy, either intensity-modulated radiation therapy or stereotactic ablative radiation therapy, in conjunction with a rectal spacer, is an efficacious means to reduce acute and long-term rectal toxicity.

AB - Prostate cancer is the most common cancer in men. External beam radiotherapy by a variety of methods is a standard treatment option with excellent disease control. However, acute and late rectal side effects remain a limiting concern in intensification of therapy in higher-risk patients and in efforts to reduce treatment burden in others. A number of techniques have emerged that allow for high-radiation dose delivery to the prostate with reduced risk of rectal toxicity, including image-guided intensity-modulated radiation therapy, endorectal balloons and various forms of rectal spacers. Image-guided radiation therapy, either intensity-modulated radiation therapy or stereotactic ablative radiation therapy, in conjunction with a rectal spacer, is an efficacious means to reduce acute and long-term rectal toxicity.

KW - endorectal balloon

KW - erectile dysfunction

KW - prostate cancer

KW - radiation therapy

KW - rectal spacer

KW - rectal toxicity

KW - stereotactic ablative radiotherapy

KW - stereotactic body radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85055610387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055610387&partnerID=8YFLogxK

U2 - 10.2217/fon-2018-0286

DO - 10.2217/fon-2018-0286

M3 - Review article

C2 - 29939069

AN - SCOPUS:85055610387

VL - 14

SP - 2773

EP - 2788

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 26

ER -