Introduction: Partial nephrectomy is being performed more frequently for small, incidentally discovered, low-stage renal tumors. The main advantage of partial nephrectomy is the avoidance of renal insufficiency. The aim of this study is to analyze the outcome of patients who have undergone nephron sparing surgery in our clinic and question the clinical role of intra-operative frozen-section analysis for determining the negative surgical margins. Materials and Methods: Forty-five patients who underwent nephron-sparing surgery between 1997 and 2006 with complete follow-up data available were included to the study. Of these patients, 42 had NSS, while 3 had radical nephrectomy because of the positive surgical margins in frozen section analysis. Indication for nephron-sparing surgery was absolute in 9.6% and elective in 90.4% of the patients. Clinical characteristics, operative findings, pathologic results and follow-up data of these patients were retrospectively analyzed. Results: The mean age and mean tumor size of the 42 patients with NSS were 51.5±12.5 (range: 24-76) years and 3.79±1.6 (2-10) cm, respectively. Histopathological analysis revealed renal cell carcinoma (RCC), oncocytoma and angiomyolipoma in 69% (n: 29), 19% (n: 8) and 11.9% (n: 5) of the patients, respectively. No significant intraoperative complication occurred. Among RCC patients, 65.5% had clear cell, 20.6% had papillary, 10.3% had chromopobe and 3.4% had eosinophilic histologic subtype. Fuhrman nuclear grade of 1, 2, 3 and 4 was evident in 1 (%3.4), 22 (%75.8), 5 (%17.2) and 1 (%3.4) patient, respectively. After a mean follow-up period of 26.0±21.6 (2-84) months, 2 (7.4%) out of 27 RCC patients had experienced recurrent disease. Conclusion: In the present study, recurrence rate after nephron-sparing surgery was found to be 7.4% which is quite similar to the literature. However, predictive factors for recurrent disease could not be determined due to the limited number of patients. Despite its reliability for determining the negative surgical margins, frozen section analysis has no impact on local recurrence and distant metastasis. For this reason, the routine use of frozen section analysis should be questioned in the light of the more extensive studies.
|Translated title of the contribution||Recurrence after nephron sparing surgery and the role of intra-operative frozen-section analysis|
|Number of pages||6|
|Journal||Turk Uroloji Dergisi|
|State||Published - Sep 1 2006|
- Renal tumor
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