Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

J. S. Abramson; E. L. Mills; M. K. Sawyer; W. R. Regelmann; J. D. Nelson; P. G. Quie

doi:10.1016/S0022-3476(81)80011-X

Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

J. S. Abramson, E. L. Mills, M. K. Sawyer, W. R. Regelmann, J. D. Nelson, P. G. Quie

Research output: Contribution to journal › Article › peer-review

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Abstract

An 18-month-old infant with delayed separation of the umbilical cord and severe recurrent bacterialinfections since the newborn period was found to have depressed polymorphonuclear leukocyte locomotion and oxidative metabolic response to particulate stimuli. Both her polymorphonuclear leukocytes and monocytes demonstrated a markedly delayed chemiluminescence response to zymosan, but there was a normal chemiluminescence response to soluble stimuli, phorbol myristate acetate and calcium ionophore A23187. The patient also had a marked delay in uptake of Staphylococcus aureus and Escherichia coli. The patient's polymorphonuclear leukocytes were normal morphologically, and myeloperoxidase was present in histochemical stains. The dichotomy between normal oxidative response to soluble stimuli and abnormal response to opsonized particulate stimuli, plus abnormal cell locomotion and phagocytosis, suggest an agnormality of cell membrane fluidity or contractility.

Original language	English (US)
Pages (from-to)	887-894
Number of pages	8
Journal	The Journal of pediatrics
Volume	99
Issue number	6
DOIs	https://doi.org/10.1016/S0022-3476(81)80011-X
State	Published - Dec 1981

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(81)80011-X

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title = "Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis",

abstract = "An 18-month-old infant with delayed separation of the umbilical cord and severe recurrent bacterialinfections since the newborn period was found to have depressed polymorphonuclear leukocyte locomotion and oxidative metabolic response to particulate stimuli. Both her polymorphonuclear leukocytes and monocytes demonstrated a markedly delayed chemiluminescence response to zymosan, but there was a normal chemiluminescence response to soluble stimuli, phorbol myristate acetate and calcium ionophore A23187. The patient also had a marked delay in uptake of Staphylococcus aureus and Escherichia coli. The patient's polymorphonuclear leukocytes were normal morphologically, and myeloperoxidase was present in histochemical stains. The dichotomy between normal oxidative response to soluble stimuli and abnormal response to opsonized particulate stimuli, plus abnormal cell locomotion and phagocytosis, suggest an agnormality of cell membrane fluidity or contractility.",

author = "Abramson, {J. S.} and Mills, {E. L.} and Sawyer, {M. K.} and Regelmann, {W. R.} and Nelson, {J. D.} and Quie, {P. G.}",

note = "Funding Information: From the Department of Pediatrics, University of Minnesota Medical School, and University of Texas Southwest Medical School Supported by training grant No. T32 AI 07054 and research grants No. 5RO1 AI 0693-15 and No. 2RO1 AI 08821-10, National Institute of Allergy and Infectious Diseases, and American Legion Heart Research Professorship. Presented in part at the International Symposium on Infections in the Immunocompromised Host, June 1-5, 1980, The Netherlands'. *Reprint address: Department of Pediatrics, Bowman Gray School of Medicine, 300 S. Hawthorne A ve., Winston-Salem, NC 27103",

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AU - Regelmann, W. R.

AU - Nelson, J. D.

AU - Quie, P. G.

N1 - Funding Information: From the Department of Pediatrics, University of Minnesota Medical School, and University of Texas Southwest Medical School Supported by training grant No. T32 AI 07054 and research grants No. 5RO1 AI 0693-15 and No. 2RO1 AI 08821-10, National Institute of Allergy and Infectious Diseases, and American Legion Heart Research Professorship. Presented in part at the International Symposium on Infections in the Immunocompromised Host, June 1-5, 1980, The Netherlands'. *Reprint address: Department of Pediatrics, Bowman Gray School of Medicine, 300 S. Hawthorne A ve., Winston-Salem, NC 27103

PY - 1981/12

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AB - An 18-month-old infant with delayed separation of the umbilical cord and severe recurrent bacterialinfections since the newborn period was found to have depressed polymorphonuclear leukocyte locomotion and oxidative metabolic response to particulate stimuli. Both her polymorphonuclear leukocytes and monocytes demonstrated a markedly delayed chemiluminescence response to zymosan, but there was a normal chemiluminescence response to soluble stimuli, phorbol myristate acetate and calcium ionophore A23187. The patient also had a marked delay in uptake of Staphylococcus aureus and Escherichia coli. The patient's polymorphonuclear leukocytes were normal morphologically, and myeloperoxidase was present in histochemical stains. The dichotomy between normal oxidative response to soluble stimuli and abnormal response to opsonized particulate stimuli, plus abnormal cell locomotion and phagocytosis, suggest an agnormality of cell membrane fluidity or contractility.

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Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

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