Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

J. S. Abramson, E. L. Mills, M. K. Sawyer, W. R. Regelmann, J. D. Nelson, P. G. Quie

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

An 18-month-old infant with delayed separation of the umbilical cord and severe recurrent bacterialinfections since the newborn period was found to have depressed polymorphonuclear leukocyte locomotion and oxidative metabolic response to particulate stimuli. Both her polymorphonuclear leukocytes and monocytes demonstrated a markedly delayed chemiluminescence response to zymosan, but there was a normal chemiluminescence response to soluble stimuli, phorbol myristate acetate and calcium ionophore A23187. The patient also had a marked delay in uptake of Staphylococcus aureus and Escherichia coli. The patient's polymorphonuclear leukocytes were normal morphologically, and myeloperoxidase was present in histochemical stains. The dichotomy between normal oxidative response to soluble stimuli and abnormal response to opsonized particulate stimuli, plus abnormal cell locomotion and phagocytosis, suggest an agnormality of cell membrane fluidity or contractility.

Original languageEnglish (US)
Pages (from-to)887-894
Number of pages8
JournalThe Journal of Pediatrics
Volume99
Issue number6
DOIs
StatePublished - 1981

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Umbilical Cord
Phagocytes
Phagocytosis
Cell Movement
Neutrophils
Luminescence
Infection
Cytophagocytosis
Membrane Fluidity
Zymosan
Calcium Ionophores
Calcimycin
Tetradecanoylphorbol Acetate
Locomotion
Peroxidase
Staphylococcus aureus
Monocytes
Coloring Agents
Cell Membrane
Newborn Infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis. / Abramson, J. S.; Mills, E. L.; Sawyer, M. K.; Regelmann, W. R.; Nelson, J. D.; Quie, P. G.

In: The Journal of Pediatrics, Vol. 99, No. 6, 1981, p. 887-894.

Research output: Contribution to journalArticle

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