TY - GEN
T1 - Red blood cell distribution effect on lung diffusing capacity
T2 - ASME 2000 International Mechanical Engineering Congress and Exposition, IMECE 2000
AU - Kulish, Vladimir V.
AU - Lage, Jose L.
AU - Hsia, Connie C.W.
AU - Johnson, Robert L.
N1 - Publisher Copyright:
© 2000 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 2000
Y1 - 2000
N2 - A novel mathematical model derived from fundamentalengineering principles for simulating the spatial and temporal gasdiffusion process within the alveolar region of the lung was presentedrecently by Koulich et al. [1]. The model depends on a physicalproperty of the alveolar region termed effective diffusivity, function ofthe diffusivity, solubility, and interface geometry of each alveolarconstituent. Unfortunately, the direct determination of the effectivediffusivity of the alveolar region is impractical because of thedifficulty in describing the internal geometry of each alveolarconstituent. However, the transient solution of the macroscopic modelcan be used in conjunction with the lung diffusing capacity (measuredin laboratory via the single-breath technique) to determine theeffective diffusivity of the alveolar region. With the effectivediffusivity known, the three-dimensional effects of red blood celldistribution on the lung diffusing capacity can be predicted vianumerical simulations. The results, obtained for normal (random),uniform, center-cluster, corner-cluster, and several chain-likedistributions, unveil a strong relationship between the type of celldistribution and the lung diffusing capacity.
AB - A novel mathematical model derived from fundamentalengineering principles for simulating the spatial and temporal gasdiffusion process within the alveolar region of the lung was presentedrecently by Koulich et al. [1]. The model depends on a physicalproperty of the alveolar region termed effective diffusivity, function ofthe diffusivity, solubility, and interface geometry of each alveolarconstituent. Unfortunately, the direct determination of the effectivediffusivity of the alveolar region is impractical because of thedifficulty in describing the internal geometry of each alveolarconstituent. However, the transient solution of the macroscopic modelcan be used in conjunction with the lung diffusing capacity (measuredin laboratory via the single-breath technique) to determine theeffective diffusivity of the alveolar region. With the effectivediffusivity known, the three-dimensional effects of red blood celldistribution on the lung diffusing capacity can be predicted vianumerical simulations. The results, obtained for normal (random),uniform, center-cluster, corner-cluster, and several chain-likedistributions, unveil a strong relationship between the type of celldistribution and the lung diffusing capacity.
KW - Lung diffusion
KW - Numerical simulation
KW - Transient
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U2 - 10.1115/IMECE2000-2228
DO - 10.1115/IMECE2000-2228
M3 - Conference contribution
AN - SCOPUS:85119673154
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 113
EP - 119
BT - Advances in Heat and Mass Transfer in Biotechnology
PB - American Society of Mechanical Engineers (ASME)
Y2 - 5 November 2000 through 10 November 2000
ER -