Redefining bronchioloalveolar carcinoma

Janessa J. Laskin, Alan B. Sandler, David H. Johnson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Bronchioloalveolar carcinoma (BAC) is a subtype of non-small cell lung cancer (NSCLC) with distinct clinical and pathologic features. Although BAC appears to be on a pathologic continuum with adenocarcinoma, the most recent World Health Organization (WHO) classification system has set stringent criteria for the diagnosis. Though malignant, these cancers tend to be peripheral and grow in a lepedic fashion along the alveolar septae without parenchymal invasion. This clear distinction based on histopathology allows for a more definite separation of the natural history and behavior of BAC in clinical studies. Recent clinical trials of molecular targeted anticancer therapies have led to a deeper understanding of the unique features of this cancer and suggest that BAC may require a different therapeutic paradigm from other NSCLCs.

Original languageEnglish (US)
Pages (from-to)329-335
Number of pages7
JournalSeminars in oncology
Volume32
Issue number3 SOPEC. ISS
DOIs
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Hematology
  • Oncology

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