Redesigning nature's poisons to create anti-tumor reagents

Ellen S. Vitetta, R. Jerrold Fulton, Richard D. May, Mark Till, Jonathan W. Uhr

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

Original languageEnglish (US)
Pages (from-to)1098-1104
Number of pages7
JournalScience
Volume238
Issue number4830
StatePublished - 1987

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Immunotoxins
Poisons
Neoplasms
Cohort Effect
Genetic Engineering
Pharmacokinetics
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Vitetta, E. S., Fulton, R. J., May, R. D., Till, M., & Uhr, J. W. (1987). Redesigning nature's poisons to create anti-tumor reagents. Science, 238(4830), 1098-1104.

Redesigning nature's poisons to create anti-tumor reagents. / Vitetta, Ellen S.; Fulton, R. Jerrold; May, Richard D.; Till, Mark; Uhr, Jonathan W.

In: Science, Vol. 238, No. 4830, 1987, p. 1098-1104.

Research output: Contribution to journalArticle

Vitetta, ES, Fulton, RJ, May, RD, Till, M & Uhr, JW 1987, 'Redesigning nature's poisons to create anti-tumor reagents', Science, vol. 238, no. 4830, pp. 1098-1104.
Vitetta ES, Fulton RJ, May RD, Till M, Uhr JW. Redesigning nature's poisons to create anti-tumor reagents. Science. 1987;238(4830):1098-1104.
Vitetta, Ellen S. ; Fulton, R. Jerrold ; May, Richard D. ; Till, Mark ; Uhr, Jonathan W. / Redesigning nature's poisons to create anti-tumor reagents. In: Science. 1987 ; Vol. 238, No. 4830. pp. 1098-1104.
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