Redesigning nature's poisons to create anti-tumor reagents

Ellen S. Vitetta; R. Jerrold Fulton; Richard D. May; Mark Till; Jonathan W. Uhr

doi:10.1126/science.3317828

Redesigning nature's poisons to create anti-tumor reagents

Ellen S. Vitetta, R. Jerrold Fulton, Richard D. May, Mark Till, Jonathan W. Uhr

Research output: Contribution to journal › Article › peer-review

324 Scopus citations

Abstract

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

Original language	English (US)
Pages (from-to)	1098-1104
Number of pages	7
Journal	Science
Volume	238
Issue number	4830
DOIs	https://doi.org/10.1126/science.3317828
State	Published - 1987

ASJC Scopus subject areas

General

Access to Document

10.1126/science.3317828

Cite this

@article{104a8bfa03a54bb6b7479ab1ffe5f684,

title = "Redesigning nature's poisons to create anti-tumor reagents",

abstract = "Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.",

author = "Vitetta, {Ellen S.} and Fulton, {R. Jerrold} and May, {Richard D.} and Mark Till and Uhr, {Jonathan W.}",

year = "1987",

doi = "10.1126/science.3317828",

language = "English (US)",

volume = "238",

pages = "1098--1104",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4830",

}

TY - JOUR

T1 - Redesigning nature's poisons to create anti-tumor reagents

AU - Vitetta, Ellen S.

AU - Fulton, R. Jerrold

AU - May, Richard D.

AU - Till, Mark

AU - Uhr, Jonathan W.

PY - 1987

Y1 - 1987

N2 - Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

AB - Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023485290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023485290&partnerID=8YFLogxK

U2 - 10.1126/science.3317828

DO - 10.1126/science.3317828

M3 - Article

C2 - 3317828

AN - SCOPUS:0023485290

SN - 0036-8075

VL - 238

SP - 1098

EP - 1104

JO - Science

JF - Science

IS - 4830

ER -

Redesigning nature's poisons to create anti-tumor reagents

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this