Redesigning nature's poisons to create anti-tumor reagents

Ellen S. Vitetta, R. Jerrold Fulton, Richard D. May, Mark Till, Jonathan W. Uhr

Research output: Contribution to journalArticle

281 Scopus citations

Abstract

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

Original languageEnglish (US)
Pages (from-to)1098-1104
Number of pages7
JournalScience
Volume238
Issue number4830
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • General

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    Vitetta, E. S., Fulton, R. J., May, R. D., Till, M., & Uhr, J. W. (1987). Redesigning nature's poisons to create anti-tumor reagents. Science, 238(4830), 1098-1104. https://doi.org/10.1126/science.3317828