Redox rescues virus from ER trap

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalNature cell biology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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