Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders

Leah H. Rubin, C. Sue Carter, Jeffrey R. Bishop, Hossein Pournajafi-Nazarloo, Lauren L. Drogos, S. Kristian Hill, Anthony C. Ruocco, Sarah K. Keedy, James L. Reilly, Matcheri S. Keshavan, Godfrey D. Pearlson, Carol A. Tamminga, Elliot S. Gershon, John A. Sweeney

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Oxytocin (OT) and arginine vasopressin (AVP) exert robust influence on social affiliation and specific cognitive processes in healthy individuals. Abnormalities in these neuroendocrine systems have been observed in psychotic disorders, but their relation to impairments in behavioral domains that these endocrines modulate is not well understood. We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66) and examined their association with emotion processing and cognition. AVP levels were lower in schizophrenia (P =. 002) and bipolar probands (P =. 03) and in relatives of schizophrenia probands (P =. 002) compared with controls. OT levels did not differ between groups. Familiality estimates were robust for OT (h 2 = 0.79, P = 3.97e-15) and AVP (h 2 = 0.78, P = 3.93e-11). Higher levels of OT were associated with better emotion recognition (β = 0.40, P <. 001) and general neuropsychological function (β = 0.26, P =. 04) in healthy controls as expected but not in any proband or relative group. In schizophrenia, higher OT levels were related to greater positive symptom severity. The dissociation of OT levels and behavioral function in all proband and relative groups suggests that risk and illness factors associated with psychotic disorders are not related to reduced OT levels but to a disruption in the ability of physiological levels of OT to modulate social cognition and neuropsychological function. Decreased AVP levels may be a marker of biological vulnerability in schizophrenia because alterations were seen in probands and relatives, and familiality was high.

Original languageEnglish (US)
Pages (from-to)1374-1384
Number of pages11
JournalSchizophrenia Bulletin
Volume40
Issue number6
DOIs
StatePublished - Nov 1 2014

Fingerprint

Oxytocin
Vasopressins
Psychotic Disorders
Arginine Vasopressin
Schizophrenia
Cognition
Emotions
Neurosecretory Systems
Aptitude
Bipolar Disorder
Biomarkers
Serum

Keywords

  • bipolar disorder
  • emotion recognition
  • oxytocin/vasopressin
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Rubin, L. H., Sue Carter, C., Bishop, J. R., Pournajafi-Nazarloo, H., Drogos, L. L., Kristian Hill, S., ... Sweeney, J. A. (2014). Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin, 40(6), 1374-1384. https://doi.org/10.1093/schbul/sbu027

Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. / Rubin, Leah H.; Sue Carter, C.; Bishop, Jeffrey R.; Pournajafi-Nazarloo, Hossein; Drogos, Lauren L.; Kristian Hill, S.; Ruocco, Anthony C.; Keedy, Sarah K.; Reilly, James L.; Keshavan, Matcheri S.; Pearlson, Godfrey D.; Tamminga, Carol A.; Gershon, Elliot S.; Sweeney, John A.

In: Schizophrenia Bulletin, Vol. 40, No. 6, 01.11.2014, p. 1374-1384.

Research output: Contribution to journalArticle

Rubin, LH, Sue Carter, C, Bishop, JR, Pournajafi-Nazarloo, H, Drogos, LL, Kristian Hill, S, Ruocco, AC, Keedy, SK, Reilly, JL, Keshavan, MS, Pearlson, GD, Tamminga, CA, Gershon, ES & Sweeney, JA 2014, 'Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders', Schizophrenia Bulletin, vol. 40, no. 6, pp. 1374-1384. https://doi.org/10.1093/schbul/sbu027
Rubin LH, Sue Carter C, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Kristian Hill S et al. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin. 2014 Nov 1;40(6):1374-1384. https://doi.org/10.1093/schbul/sbu027
Rubin, Leah H. ; Sue Carter, C. ; Bishop, Jeffrey R. ; Pournajafi-Nazarloo, Hossein ; Drogos, Lauren L. ; Kristian Hill, S. ; Ruocco, Anthony C. ; Keedy, Sarah K. ; Reilly, James L. ; Keshavan, Matcheri S. ; Pearlson, Godfrey D. ; Tamminga, Carol A. ; Gershon, Elliot S. ; Sweeney, John A. / Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. In: Schizophrenia Bulletin. 2014 ; Vol. 40, No. 6. pp. 1374-1384.
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