Reduced Na+, K+-ATPase activity in intact red cells and isolated membranes from obese man

I. Klimes, M. Nagulesparan, Roger H Unger, S. L. Aronoff, D. M. Mott

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Na+, K+-ATPase activity was measured in red blood cells from 20 nondiabetic euthyroid male Pima Indians with varying degrees of obesity; their body mass indices ranged from 22�60 kg/m2. The Na+, K+-ATPase, measured both by 86Rb uptake inintact cells and ATP hydrolysis by purified membranes, was inversely correlated with bodymass index (r = �0.62; P < 0.005 and r = �0.75; P < 0.0001, respectively). These results confirm that obesity is associated with decreased Na+, K+-ATPase in intact red blood cells, and provide the first demonstration of a reduced sodium pump in isolated red cell membrane preparations from obese men.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number4
DOIs
StatePublished - Apr 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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