Reduced platelet cytochrome c oxidase activity in alzheimer’s disease

W. D. Parker, N. J. Mahr, C. M. Filley, J. K. Parks, D. Hughes, D. A. Young, C. M. Cullum

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec−1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec−1/mg, p=0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.

Original languageEnglish (US)
Pages (from-to)1086-1090
Number of pages5
JournalNeurology
Volume44
Issue number6
DOIs
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Clinical Neurology

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