Abstract
We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec−1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec−1/mg, p=0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.
Original language | English (US) |
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Pages (from-to) | 1086-1090 |
Number of pages | 5 |
Journal | Neurology |
Volume | 44 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1994 |
ASJC Scopus subject areas
- Clinical Neurology