Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

W. D. Parker, N. J. Mahr, C. M. Filley, J. K. Parks, D. Hughes, D. A. Young, C. M. Cullum

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Abstract

We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec-1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec-1/mg, p = 0.0333. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.

Original languageEnglish (US)
Pages (from-to)1086-1090
Number of pages5
JournalNeurology
Volume44
Issue number6
StatePublished - Jun 1994

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Electron Transport Complex IV
Alzheimer Disease
Blood Platelets
Citrate (si)-Synthase
Succinate Dehydrogenase
Electron Transport Complex III
Cytochromes c
Oxidoreductases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Parker, W. D., Mahr, N. J., Filley, C. M., Parks, J. K., Hughes, D., Young, D. A., & Cullum, C. M. (1994). Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology, 44(6), 1086-1090.

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. / Parker, W. D.; Mahr, N. J.; Filley, C. M.; Parks, J. K.; Hughes, D.; Young, D. A.; Cullum, C. M.

In: Neurology, Vol. 44, No. 6, 06.1994, p. 1086-1090.

Research output: Contribution to journalArticle

Parker, WD, Mahr, NJ, Filley, CM, Parks, JK, Hughes, D, Young, DA & Cullum, CM 1994, 'Reduced platelet cytochrome c oxidase activity in Alzheimer's disease', Neurology, vol. 44, no. 6, pp. 1086-1090.
Parker WD, Mahr NJ, Filley CM, Parks JK, Hughes D, Young DA et al. Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology. 1994 Jun;44(6):1086-1090.
Parker, W. D. ; Mahr, N. J. ; Filley, C. M. ; Parks, J. K. ; Hughes, D. ; Young, D. A. ; Cullum, C. M. / Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. In: Neurology. 1994 ; Vol. 44, No. 6. pp. 1086-1090.
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