Reduced REM latency predicts response to tricyclic medication in depressed outpatients

A. John Rush, Donna E. Giles, Robin B. Jarrett, Frida Feldman-Koffler, John R. Debus, Jan Weissenburger, Paul J. Orsulak, Howard P. Roffwarg

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Forty-two outpatients with major depressive disorder entered a double-blind, randomized trial of either desipramine or amitriptyline for a minimum of 6 weeks. Pretreatment polysomnographic and clinical measures were used to predict response. Response was defined as a 17-item Hamilton Rating Scale for Depression score ≤9 at the end of treatment. There was a 61.1% response rate for patients treated with amitriptyline and a 66.7% response rate for patients treated with desipramine. Reduced REM latency (2-night mean ≤65.0 min) predicted a positive response to these tricyclic antidepressants. REM latency did not differentiate between desipramine or amitriptyline responders. More patients with reduced REM latency (80%) responded to treatment compared with patients with nonreduced REM latency (50%). The 80% response rate in reduced REM latency depressed patients confirms our previous findings in a mixed inpatient and outpatient sample. Contrary to our hypothesis, in this sample, endogenous depression was not associated with a good response to tricyclic medication.

Original languageEnglish (US)
Pages (from-to)61-72
Number of pages12
JournalBiological Psychiatry
Issue number1
StatePublished - May 1989

ASJC Scopus subject areas

  • Biological Psychiatry


Dive into the research topics of 'Reduced REM latency predicts response to tricyclic medication in depressed outpatients'. Together they form a unique fingerprint.

Cite this