@article{c8cfbf1e8b50430b902d2f389e313c84,
title = "Reduced REM latency predicts response to tricyclic medication in depressed outpatients",
abstract = "Forty-two outpatients with major depressive disorder entered a double-blind, randomized trial of either desipramine or amitriptyline for a minimum of 6 weeks. Pretreatment polysomnographic and clinical measures were used to predict response. Response was defined as a 17-item Hamilton Rating Scale for Depression score ≤9 at the end of treatment. There was a 61.1% response rate for patients treated with amitriptyline and a 66.7% response rate for patients treated with desipramine. Reduced REM latency (2-night mean ≤65.0 min) predicted a positive response to these tricyclic antidepressants. REM latency did not differentiate between desipramine or amitriptyline responders. More patients with reduced REM latency (80%) responded to treatment compared with patients with nonreduced REM latency (50%). The 80% response rate in reduced REM latency depressed patients confirms our previous findings in a mixed inpatient and outpatient sample. Contrary to our hypothesis, in this sample, endogenous depression was not associated with a good response to tricyclic medication.",
author = "Rush, {A. John} and Giles, {Donna E.} and Jarrett, {Robin B.} and Frida Feldman-Koffler and Debus, {John R.} and Jan Weissenburger and Orsulak, {Paul J.} and Roffwarg, {Howard P.}",
note = "Funding Information: From the Mental Health Clinical Research Center and Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX (A.J.R., R.B.J., F.F.K., J.R.D., J. W., H.P.R.); the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA (D.E.G.); and the Psychiatric Clinical Diagnostic Laboratory, VA Medical Center, Dallas, TX (P.J.O.) Presented in part at the annual meeting of the Society of Biological Psychiatry, Chicago, IL, May 1987. Supported by NIMH Grant MH-35370 (A.J.R.); NIH General Clinical Research Center Grant MOlRROO633 to the Depanment of Internal Medicine, UT Southwestern; NIMH Mental Health Clinical Research Center Grant MH-4 I I I 5 to the Depanment of Psychiatry, UT Southwestern; and by a grant from the Waters Division of Millipore, Inc. (P.J.O.) Address reprint requests to Dr. A. John Rush, Mental Health Clinical Research Center, Department of Psychiatry. 5323 Hmy Hines Blvd., Dallas, TX 75235. Received December 12, 1987; revised July 27, 198X.",
year = "1989",
month = may,
doi = "10.1016/0006-3223(89)90008-5",
language = "English (US)",
volume = "26",
pages = "61--72",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "1",
}