Abstract
Forty-two outpatients with major depressive disorder entered a double-blind, randomized trial of either desipramine or amitriptyline for a minimum of 6 weeks. Pretreatment polysomnographic and clinical measures were used to predict response. Response was defined as a 17-item Hamilton Rating Scale for Depression score ≤9 at the end of treatment. There was a 61.1% response rate for patients treated with amitriptyline and a 66.7% response rate for patients treated with desipramine. Reduced REM latency (2-night mean ≤65.0 min) predicted a positive response to these tricyclic antidepressants. REM latency did not differentiate between desipramine or amitriptyline responders. More patients with reduced REM latency (80%) responded to treatment compared with patients with nonreduced REM latency (50%). The 80% response rate in reduced REM latency depressed patients confirms our previous findings in a mixed inpatient and outpatient sample. Contrary to our hypothesis, in this sample, endogenous depression was not associated with a good response to tricyclic medication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-72 |
| Number of pages | 12 |
| Journal | Biological Psychiatry |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Biological Psychiatry
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Reduced REM latency predicts response to tricyclic medication in depressed outpatients. / Rush, A. John; Giles, Donna E.; Jarrett, Robin B.; Feldman-Koffler, Frida; Debus, John R.; Weissenburger, Jan; Orsulak, Paul J.; Roffwarg, Howard P.
In: Biological Psychiatry, Vol. 26, No. 1, 1989, p. 61-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced REM latency predicts response to tricyclic medication in depressed outpatients
AU - Rush, A. John
AU - Giles, Donna E.
AU - Jarrett, Robin B.
AU - Feldman-Koffler, Frida
AU - Debus, John R.
AU - Weissenburger, Jan
AU - Orsulak, Paul J.
AU - Roffwarg, Howard P.
PY - 1989
Y1 - 1989
N2 - Forty-two outpatients with major depressive disorder entered a double-blind, randomized trial of either desipramine or amitriptyline for a minimum of 6 weeks. Pretreatment polysomnographic and clinical measures were used to predict response. Response was defined as a 17-item Hamilton Rating Scale for Depression score ≤9 at the end of treatment. There was a 61.1% response rate for patients treated with amitriptyline and a 66.7% response rate for patients treated with desipramine. Reduced REM latency (2-night mean ≤65.0 min) predicted a positive response to these tricyclic antidepressants. REM latency did not differentiate between desipramine or amitriptyline responders. More patients with reduced REM latency (80%) responded to treatment compared with patients with nonreduced REM latency (50%). The 80% response rate in reduced REM latency depressed patients confirms our previous findings in a mixed inpatient and outpatient sample. Contrary to our hypothesis, in this sample, endogenous depression was not associated with a good response to tricyclic medication.
AB - Forty-two outpatients with major depressive disorder entered a double-blind, randomized trial of either desipramine or amitriptyline for a minimum of 6 weeks. Pretreatment polysomnographic and clinical measures were used to predict response. Response was defined as a 17-item Hamilton Rating Scale for Depression score ≤9 at the end of treatment. There was a 61.1% response rate for patients treated with amitriptyline and a 66.7% response rate for patients treated with desipramine. Reduced REM latency (2-night mean ≤65.0 min) predicted a positive response to these tricyclic antidepressants. REM latency did not differentiate between desipramine or amitriptyline responders. More patients with reduced REM latency (80%) responded to treatment compared with patients with nonreduced REM latency (50%). The 80% response rate in reduced REM latency depressed patients confirms our previous findings in a mixed inpatient and outpatient sample. Contrary to our hypothesis, in this sample, endogenous depression was not associated with a good response to tricyclic medication.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024383987&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(89)90008-5
DO - 10.1016/0006-3223(89)90008-5
M3 - Article
C2 - 2655719
AN - SCOPUS:0024383987
VL - 26
SP - 61
EP - 72
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -