Reducing major risk factors for chronic kidney disease

Valerie A. Luyckx, Katherine R. Tuttle, Guillermo Garcia-Garcia, Mohammed Benghanem Gharbi, Hiddo J.L. Heerspink, David W. Johnson, Zhi Hong Liu, Ziad A. Massy, Orson Moe, Robert G. Nelson, Laura Sola, David C. Wheeler, Sarah L. White

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is a global public health concern and a key determinant of poor health outcomes. While the burden of CKD is reasonably well defined in developed countries, increasing evidence indicates that the CKD burden may be even greater in developing countries. Diabetes, hypertension, and obesity are major contributors to the global burden of the disease and are important traditional CKD risk factors; however, nontraditional CKD risk factors such as nephrotoxin exposure, kidney stones, fetal and maternal factors, infections, environmental factors, and acute kidney injury are also increasingly being recognized as major threats to global kidney health. A broad approach to CKD prevention begins with the identification of CKD risk factors in the population, followed by the development of appropriate mitigation strategies. Effective prevention policies rely on an accurate understanding of the incidence and prevalence of CKD in a given setting, as well as the distribution and burden of risk factors. Populations or individuals at CKD risk must be screened and treated early to prevent the onset of and delay the progression of the kidney disease. Systematically collected data should be analyzed at country, province, and district levels to identify regional disparities and CKD hotspots and develop targeted prevention strategies. Race-ethnicity, genetics, sex, socioeconomic status, and geography are likely modifiers of CKD risk. A comprehensive, informed approach to prevention that takes into account all of these factors is therefore required to successfully tackle the global CKD epidemic.

Original languageEnglish (US)
Pages (from-to)71-87
Number of pages17
JournalKidney International Supplements
Volume7
Issue number2
DOIs
StatePublished - Oct 1 2017

Fingerprint

Chronic Renal Insufficiency
Geography
Kidney Calculi
Kidney Diseases
Acute Kidney Injury
Developed Countries
Social Class
Population
Developing Countries
Public Health
Obesity
Mothers
Hypertension
Kidney

Keywords

  • acute kidney injury
  • chronic kidney disease
  • multi-sectoral approach
  • prevention
  • public health
  • risk factors

ASJC Scopus subject areas

  • Nephrology

Cite this

Luyckx, V. A., Tuttle, K. R., Garcia-Garcia, G., Gharbi, M. B., Heerspink, H. J. L., Johnson, D. W., ... White, S. L. (2017). Reducing major risk factors for chronic kidney disease. Kidney International Supplements, 7(2), 71-87. https://doi.org/10.1016/j.kisu.2017.07.003

Reducing major risk factors for chronic kidney disease. / Luyckx, Valerie A.; Tuttle, Katherine R.; Garcia-Garcia, Guillermo; Gharbi, Mohammed Benghanem; Heerspink, Hiddo J.L.; Johnson, David W.; Liu, Zhi Hong; Massy, Ziad A.; Moe, Orson; Nelson, Robert G.; Sola, Laura; Wheeler, David C.; White, Sarah L.

In: Kidney International Supplements, Vol. 7, No. 2, 01.10.2017, p. 71-87.

Research output: Contribution to journalReview article

Luyckx, VA, Tuttle, KR, Garcia-Garcia, G, Gharbi, MB, Heerspink, HJL, Johnson, DW, Liu, ZH, Massy, ZA, Moe, O, Nelson, RG, Sola, L, Wheeler, DC & White, SL 2017, 'Reducing major risk factors for chronic kidney disease', Kidney International Supplements, vol. 7, no. 2, pp. 71-87. https://doi.org/10.1016/j.kisu.2017.07.003
Luyckx VA, Tuttle KR, Garcia-Garcia G, Gharbi MB, Heerspink HJL, Johnson DW et al. Reducing major risk factors for chronic kidney disease. Kidney International Supplements. 2017 Oct 1;7(2):71-87. https://doi.org/10.1016/j.kisu.2017.07.003
Luyckx, Valerie A. ; Tuttle, Katherine R. ; Garcia-Garcia, Guillermo ; Gharbi, Mohammed Benghanem ; Heerspink, Hiddo J.L. ; Johnson, David W. ; Liu, Zhi Hong ; Massy, Ziad A. ; Moe, Orson ; Nelson, Robert G. ; Sola, Laura ; Wheeler, David C. ; White, Sarah L. / Reducing major risk factors for chronic kidney disease. In: Kidney International Supplements. 2017 ; Vol. 7, No. 2. pp. 71-87.
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